Inst för medicin, Solna / Dept of Medicine, Solna: Recent submissions
Now showing items 81-100 of 802
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The impact of autoimmune thyroid disease (AITD) on rheumatoid arthritis (RA) and the impact of RA on AITD
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-02-25)Study I. Background: The Swedish National Patient Register (NPR) is a unique source for the identification of large cohorts of rheumatoid arthritis (RA) patients. The general validity of this register has been reported to ... -
Longterm outcomes in patients with acute and chronic myocardial injury
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-02-24)Background: Myocardial injury is defined as any cardiac troponin (cTn) level above the upper reference limit, namely, the 99th percentile value, and is caused by either ischemic or nonischemic events. The presence of acute ... -
Bloody big data : ensuring the health of blood donors and transfused patients with health registers
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-02-09)Blood transfusion is widely considered a pillar of modern medicine and is one of the most common medical interventions. A transfusion intimately links two persons and their health through the altruism of blood donors. In ... -
CRISPR-based drug target discovery : implications for CRISPR-based therapies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-01-04)The CRISPR system was discovered in prokaryotic cells, and it is now one of the most efficient molecular tools to modify genes in eukaryotic cells. It is widely used to inactivate or modify genes in cell lines, animal ... -
Non-coding RNA-based therapeutics and biomarkers for treatment and detection of vascular disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-12-23)Cardiovascular disease (CVD), with atherosclerosis as its main underlying pathology, is the most prominent cause of death worldwide. Progression and rupture of atherosclerotic plaques lead to potential adverse pathological ... -
Malaria in infants : asymptomatic and symptomatic infections the first year of life
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-11-19)Malaria causes the majority of deaths in children below five years of age, but asymptomatic infections are more frequent. An understanding of the interplay of human and parasite factors which predispose to symptomatic ... -
Copeptin in cardiovascular disease and dysglycemia
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-11-15)Background: The impaired prognosis in patients with cardiovascular disease (CVD) and dysglycemia is not fully explained by traditional risk markers, among them hyperglycemia and hyperlipidemia. Understanding the developmental ... -
The red blood cell as a mediator of vascular dysfunction in type 2 diabetes and COVID-19
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-11-03)Background: The number of patients diagnosed with Type 2 Diabetes (T2D) is steadily increasing and accounts for a large proportion of cardiovascular complications. Endothelial dysfunction represents an early disturbance ... -
The role of the DAMP molecule HMGB1 in neuroinflammation and macrophage activation
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-10-22)High mobility group box 1 (HMGB1) is a highly conserved nuclear protein expressed in all eukaryotic cells. While its nuclear functions are vital, we know today that HMGB1 also functions as a Damage Associated Molecular ... -
Studies on biological treatment and biomarkers in systemic lupus erythematosus : longterm effects, risk factors and predictors of response
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-10-21)Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which several immune mechanisms are involved in a complex interplay. B-cells are considered to be a major player in the pathophysiology of the disease, and the ... -
Darier disease : more than skin deep
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-10-20)Darier disease (DD) is a severe, inherited dermatological disorder with a characteristic clinical and histopathological appearance. It is caused by mutations in the ATP2A2 gene, encoding a Ca2+ pump in the endoplasmic ... -
Promoter mutations/methylation in thyroid and urothelial carcinomas : biological and clinical implications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-10-06)Genetic and epigenetic aberrations are well established to drive cancer development and progression. However, the underlying mechanisms are incompletely understood, and the translational applications of aberrant alterations ... -
Do-Not-Attempt-Cardiopulmonary-Resuscitation decisions in the hospital setting
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-10-01)Background: A Do-Not-Attempt-Cardiopulmonary-Resuscitation (DNACPR) order can be placed when CPR is not in accordance with the patient’s will, when CPR is considered not to benefit the patient, or when CPR is very unlikely ... -
Platelet-regulated CD4+ T effector cell responses in atherosclerosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-09-30)Atherosclerosis (AS) is a thrombotic and inflammatory disease of the medium- and largesized arteries. Platelets participate in all stages of its formation, forming thrombus at the ruptured plaque; meanwhile, CD4+ T cells ... -
Analysis of extracellular vesicles and their application in immunotherapy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-09-28)Extracellular Vesicles (EVs) are nano-sized particles secreted by most, if not all, cell types. They are important mediators in intercellular communication and carry a broad array of biomolecules such as lipids, nucleic ... -
Atopic dermatitis in adults : epidemiological studies of comorbidity and studies of patients on systemic treatment
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-06-01)Background: Atopic dermatitis (AD) is one of the most common chronic skin disorders globally. It is an itchy inflammatory skin disease that can have a detrimental impact on health-related quality of life. In recent years, ... -
Pharmacoepidemiologic studies of drug safety in pediatric chronic inflammatory disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-05-26)Safety evidence for use of pharmaceutical drugs in children, including treatments for serious conditions such as chronic inflammatory diseases, is generally scarce. Off-label use is common and clinicians need to rely on ... -
Risk factors and comorbidity in primary Sjögren’s syndrome
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-05-21)Primary Sjögren’s syndrome is an autoimmune disease, in which the immune system targets the exocrine glands. The disease is characterized by inflammation and dysfunction of the salivary and lacrimal glands, leading to dry ... -
Immunopeptidomics and autoantigens of interstitial lung diseases
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-05-21)We investigate Sarcoidosis and Idiopathic Pulmonary Fibrosis, IPF, to find markers for early fibrosis development. The aetiologies for both diseases are unknown and there is no specific treatment, moreover, there is a lack ... -
Psoriasis : observational studies on clinical course, economic burden and treatment
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-05-11)Better understanding of long-term prognosis, clinical course, comorbidities, economic burden, and treatment of psoriasis, can improve care of patients with the disease and may inform decisions on resource allocation, ...