Inst för medicin, Solna / Dept of Medicine, Solna: Recent submissions
Now showing items 61-80 of 802
-
Characterization of immune specificities in idiopathic inflammatory myopathies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-09-01)Idiopathic inflammatory myopathies (IIM or myositis) are a group of rheumatic autoimmune diseases characterised by skeletal muscle inflammation and weakness, and are associated with high morbidity and mortality. The diagnosis ... -
Cutaneous leishmaniasis : treatment and genetic mechanisms affecting outcome
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-08-25)Leishmaniasis is a neglected parasitic disease and a rare diagnosis in non-endemic countries in Europe. Migration, geopolitical conflicts and climate change have increased awareness of this infection in Europe, as more ... -
Cellular and molecular mechanisms for induction of broad anti-viral B cell responses through vaccination
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-08-24)Viral infections contribute to significant morbidity and mortality worldwide. The immense diversity across and within viral families poses a substantial challenge for the development of prophylaxis and therapeutics. Vaccines ... -
Beyond Th1 and Treg : intestinal T helper cells in disease and tolerance
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-08-16)The human intestinal tract is not only one of the largest organs by surface area in our bodies but also harbors the greatest number of immune cells. These cells are crucial for maintaining tolerance towards the various ... -
Pharmacoepidemiological studies of rheumatoid arthritis : methodological considerations and applications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-08-04)Study I: Biological disease-modifying anti-rheumatic drugs (DMARDs) and the risk of gastrointestinal perforations: Study I was motivated by previous signals of an increased risk of lower gastro-intestinal perforations among ... -
Development of immunomodulatory RNA therapeutics for immune disorders
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-08-03)Autoimmune diseases such as Rheumatoid Arthritis (RA) are complex and involve many different cell types. Of these cell types, T cells are thought to be key drivers of the inflammation. The current treatment options available ... -
Idiopathic pulmonary fibrosis : disease presentation, clinical course and potential biomarkers
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-05-25)The interest and research within the area of the fatal lung disease idiopathic pulmonary fibrosis (IPF) has increased exponentially over the past decades. This has resulted in important insights into the nature and ... -
Aminoacyl tRNA synthetases and their connection to autoimmune rheumatic disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-05-24)Idiopathic inflammatory myopathies (IIM, collectively called myositis) are rare autoimmune rheumatic diseases characterized by chronic inflammation and associated with high mortality and morbidity (1, 2). The disease ... -
Comprehensive assessment of device-based therapy for heart failure with reduced ejection fraction
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-05-16)Background: Despite a recommendation by the European guidelines, the use of implantable cardioverter defibrillators (ICD) for the primary prevention of sudden cardiac death (SCD) in patients with heart failure with reduced ... -
Interplay between inflammation and calcification in cardiovascular diseases
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-05-13)Cardiovascular calcification has been linked to all-cause mortality and is a broadly adopted predictor of cardiovascular (CV) events. Rather than a mere by-product of the changing disease environment, calcification impacts ... -
Malaria in travellers and migrants
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-05-11)Malaria is a potentially fatal disease that caused approximately 241 million cases and 627 000 deaths in 2020, most in children in Sub-Saharan Africa. In non-endemic countries, malaria is imported by travellers and migrants ... -
Prognostication in heart failure across ejection fraction phenotypes and challenging subgroups : data from the Swedish heart failure registry
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-05-10)Background: The growing prevalence of heart failure (HF) worldwide determines an increasing burden on healthcare systems. HF phenotypes differ for several patient characteristics. Treatments with proven efficacy are mainly ... -
Pathophysiology of critically ill covid-19 patients
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-04-29)With the onset of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a new disease, COVID-19, challenged health care professionals and scientists. The angiotensin-converting enzyme type 2 (ACE2) was ... -
Pathways linking atherosclerosis to aortic stenosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-04-28)Cardiovascular disease is the most common cause of death world-wide where atherosclerosis is the main culprit and aortic valve disease accounts about two percent of all CVD deaths. Atherosclerosis is a lipid and inflammation ... -
Oral glucose tolerance test as a prognostic tool in patients with acute coronary syndrome
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-04-22)Background: Disturbances of glucose metabolism such as type 2 diabetes and impaired glucose tolerance are established risk factors for cardiovascular disease and mortality. The disturbances lead to hyperglycaemia and the ... -
Safe labor : reappraisal of labor duration and management for safe maternal and infant outcome
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-04-19)Background: The partograph, today used worldwide for assessing normal labor progress and identifying prolonged labor is based on Friedman’s research findings from the 1950s, based on 500 deliveries. Friedman established a ... -
The role of red blood cells in cardiac and endothelial dysfunction in cardiometabolic disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-04-12)Background: Cardiometabolic disease, which includes the combination of cardiovascular disease, especially coronary artery disease and type 2 diabetes (T2D), is a major health problem and cause of mortality worldwide. ... -
Pharmacoepidemiological studies of proton pump inhibitor use in the pediatric population
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-04-11)Proton pump inhibitors (PPIs) are widely effective in the treatment of gastric acid-related disorders. Although use of PPIs has increased markedly among children and these drugs are frequently prescribed off-label in the ... -
Regulatory roles for long noncoding RNAs and circular RNAs in human skin wound repair
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-03-17)Human skin wound repair is a multiphase process, which includes inflammation, growth and remodeling, and requires the concerted communication of many cell types. During the course of healing, skin cells find themselves in ... -
Understanding inflammation requires neuroscience
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-03-01)Inflammation and its resolution are processes subject to neural regulation (1). The best-characterized immune-regulating reflex is the “inflammatory reflex”, in which the efferent branch of the vagus nerve plays a central ...