Inst för medicin, Solna / Dept of Medicine, Solna: Recent submissions
Now showing items 41-60 of 802
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The effect of Plasmodium infection on cellular aging in humans
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-17)Telomeres play an essential role in maintaining chromosomal integrity and stability. Telomere shortening is part of the natural aging process, nevertheless, accelerated telomere shortening has been linked to chronic diseases ... -
Nutrition in advanced cancer care : a clinical perspective
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-16)Adequate nutrition is an essential part in all stages of cancer care. By optimizing the nutrition care the benefits include increased tolerance to treatment as well as decreased mortality. Understanding how aspects of ... -
Diffuse large B-cell lymphoma : population-based studies of relapse and cardiac complications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-15)Diffuse large B-cell lymphoma (DLBCL) is an aggressive life-threatening disease, but it is often possible to cure with immunochemotherapy. Not responding to primary treatment or having a relapse is associated with poor ... -
Understanding the role of regulatory RNAs in human skin wound healing
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-14)Human skin wound healing is characterized by four phases in a timely manner, including hemostasis, inflammation, proliferation, and remodeling. Various cell types are involved in the biological process. Keratinocytes that ... -
Clinical and epidemiological project in cancer-associated dermatomyositis : the role of anti-TIF1γ antibodies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-01-27)Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare chronic autoimmune inflammatory diseases causing a debilitating muscle weakness but encountering even other symptoms such as arthritis, skin rash, ... -
Ultrasound and fluorescence optical imaging biomarkers for early diagnosis and prediction of rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-01-12)Prevention of rheumatoid arthritis (RA) is most desirable together with curative treatment which is, however, not yet available. Today, the correct timely diagnosis and early treatment interventions to prevent disease ... -
Resident T cells steer tissue responses in human skin
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-01-04)The human skin constitutes a biological barrier against threats to the body from the surrounding environment. Tissue-resident memory cells (TRM) reside in the skin and provide local memory of previous encounters with ... -
Charting mast cell development in health and systemic mastocytosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-12-16)Hematopoietic stem and progenitor cells give rise to various blood and immune cells, including mast cells. In adults, bone marrow hematopoietic stem cells give rise to mast cell progenitors. These mast cell progenitors ... -
Bacteremia in patients with hematological malignancies and neutropenia
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-12-14)For hematological cancer patients, the risk of blood stream infection by bacterial pathogens is increased. Studies on pathogen panorama, efficacy of antimicrobial prophylaxis and antimicrobial resistance are important ... -
Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-12-13)Inflammation is the basis for various serious illnesses such as rheumatic diseases, cardiovascular diseases, and cancer. Prostaglandin E2 (PGE2) is a pro-inflammatory lipid mediator produced by cyclooxygenases (COX1/2) and ... -
Cancer after solid organ transplantation : incidence, risk factors, and survival
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-11-25)Background: Solid organ transplant recipients (OTRs) are at increased risk of cancer compared with the general population, mainly due to post-transplant immunosuppressive treatment. Furthermore, once diagnosed with cancer, ... -
Optimising treatment outcomes in people living with systemic lupus erythematosus
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-11-11)Systemic Lupus Erythematosus (SLE) is a chronic, autoimmune disease with heterogeneous symptoms, mainly affecting females in their reproductive years. The aim of this thesis was to expand the current understanding of how ... -
Diversity and function of anti-modified protein autoantibodies in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-11-10)Rheumatoid arthritis (RA) is a chronic autoimmune disease particularly affecting synovial joints. Anti-citrullinated protein autoantibodies (ACPA) are detected in the serum of about 2/3 of RA patients and are being used ... -
Improved diagnosis and management of sepsis and bloodstream infection
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-11-08)Sepsis is a severe organ dysfunction triggered by infections, and a leading cause of hospitalization and death. Concurrent bloodstream infection (BSI) is common and around one third of sepsis patients have positive blood ... -
B cell transcriptomics and immunoglobulin genetics in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-11-02)Rheumatoid Arthritis (RA) is a complex autoimmune disease characterized by inflammation of the peripheral joints. The exact disease pathology remains to be elucidated, but it has been hypothesized that autoreactive B cells ... -
Clinical presentation and outcomes of COVID-19 compared with other respiratory virus infections and hospital populations
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-10-14)As of September 2022, more than 600 million cases of coronavirus disease 2019 (COVID-19) and 6.5 million deaths have been officially reported to the World Health Organization (WHO). The unfolding pandemic has exerted ... -
Human immune responses to SARS-Cov-2 and influenza A virus infection : from myeloid-derived suppressor cells and T cell functions to antibody responses
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-10-03)Acute respiratory viral infections are the most frequent reason for medical consultations in the world. They cause substantial illness and death every year, especially in young children, the immunocompromised and the ... -
Pain patterns in early rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-09-30)Study I: Widespread non-joint pain in early rheumatoid arthritis. Objective: The aim of the study was to assess the development of widespread non-joint pain (WNP) in a cohort of patients with early rheumatoid arthritis ... -
Systems biology approaches to investigate mechanisms of obstructive lung diseases
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-09-23)Both asthma and chronic obstructive pulmonary disease (COPD) are obstructive lung diseases with a large impact on global health, causing 400 000 and 3 million deaths respectively each year. The numbers may be underestimated, ... -
Impact of psychosocial factors on rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-09-08)In the field of rheumatology, the research has been successful in the understanding of the molecular mechanisms of the underlying pathophysiology of rheumatoid arthritis (RA). As a result of this, targeted treatments have ...