Inst för medicin, Solna / Dept of Medicine, Solna: Recent submissions
Now showing items 21-40 of 802
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Genetic risk factors in autoimmune Addison's disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-31)Autoimmune Addison’s disease is the most common form of primary adrenal insufficiency in the Western world. The low prevalence of the disease has hampered large-scale unbiased genetic studies where the entire genome could ... -
Deciphering the complexity of psoriasis : non-coding RNAs and cellular interactions
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-23)Psoriasis is a prevalent immune-mediated skin disorder marked by chronically relapsing inflammation and epidermal hyperproliferation. As researchers delve deeper into the molecular intricacies of psoriasis, emerging evidence ... -
Studies on colonoscopy and inflammatory conditions of the colon
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-20)Background: Colonoscopy is a key investigative tool in inflammatory bowel disease and diverticular disease, but elements of the pathogenesis, symptomatology and safety of procedures in these two conditions remain unknown. ... -
Prediction and monitoring of in-hospital cardiac arrest
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-16)Background: In-hospital cardiac arrest (IHCA) is a global health concern of major importance, associated with a poor prognosis. IHCA is frequently heralded by a deterioration of vital signs, and many cases are considered ... -
Composition and maintenance of skin resident T-cells in health and disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-13)Tissue-resident memory T cells (TRM) reside in healthy skin at sites of previous infections. Upon re-infection, TRM cells rapidly respond by initiating tissue inflammation and exert effector functions to eliminate ... -
Colorectal cancer in inflammatory bowel disease : aspects on post-colonoscopy colorectal cancer
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-09-27)Colorectal cancer (CRC) is the third most common cancer in the world. It is diagnosed by and can be prevented with colonoscopy combined with polyp removal. A post-colonoscopy CRC (PCCRC) is a cancer detected within 3 years ... -
"It's not a quick fix" : consequences of weight loss during life and experiences of weight regain after bariatric surgery
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-09-18)Maintenance of weight loss is challenging for most people who intentionally lose weight. Complex factors interact with each other and obstruct weight management. This thesis focuses on the consequences of weight loss and ... -
Etiology and prognosis of spondyloarthropathies using family-based epidemiological methods
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-09-13)The spondyloarthropathies (SpA) are a group of chronic inflammatory diseases that share several disease characteristics such as inflammation of entheses and extramusculoskeletal manifestations like uveitis, psoriasis, and ... -
Childhood-onset inflammatory bowel disease-health care use, impact on growth and school achievements
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-08-16)The aim of this thesis was to explore the Impact of Inflammatory bowel disease (IBD) on growth and school achievements. We also assessed the Incidence and health care use of patients with very early-onset IBD (VEO-IBD). ... -
Temporal trends in adverse pregnancy outcomes in axial spondyloarthritis in Sweden : a cohort study
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-06-30)Background: Evidence on the risks associated with pregnancy and childbirth in women with axial spondyloarthritis is scarce and conflicting, with more research needed to guide policy and clinical practice. We aimed to assess ... -
Genetic and environmental influences on multiple sclerosis complications and aetiology
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-05-22)Multiple sclerosis (MS) is an immune mediated, neurological disease that results in a chronic accumulation of disability over time. Many advances in the understanding, diagnosis and treatment of MS have been made, yet ... -
Treatment optimisation of multidrug-resistant tuberculosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-05-22)A successful treatment outcome is seen in only 60% of persons treated for multidrugresistant tuberculosis (MDR-TB) worldwide, defined as resistance to both rifampicin and isoniazid. To improve these disturbingly low numbers, ... -
Risk factors and outcomes in inflammatory myopathies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-05-04)Idiopathic inflammatory myopathies (IIM) are complex autoimmune diseases associated with high morbidity and mortality. Although knowledge about the pathogenic mechanisms underlying IIM is improving, limited data are available ... -
Studies of pathophysiological mechanisms and oral cavity manifestations in chronic inflammatory diseases
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-04-14)Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with a 9:1 female predominance where many genetic and clinical characteristics overlap with other inflammatory conditions such as rheumatoid arthritis (RA). ... -
Studies on autoantibodies and inflammatory markers in patients with idiopathic inflammatory myopathies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-04-05)Idiopathic Inflammatory myopathies (IIM), commonly known as myositis, are chronic autoimmune diseases characterized by low muscle strength and low muscle endurance as main features. However, a high number of patients may ... -
Morbidity and childbirth in myeloproliferative neoplasms
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-31)Myeloproliferative neoplasms (MPN) are a family of chronic hematologic cancers, characterized by excess proliferation of myeloid cell lineages, or fibrosis of the bone marrow. Patients with MPN generally have a long expected ... -
Dysglycaemia and cardiovascular disease. Aspects on screening, management, and prognosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-24)Background: Dysglycaemia, in this thesis defined as impaired glucose tolerance (IGT) or type 2 diabetes (T2DM), is a major risk factor for cardiovascular disease (CVD). International guidelines recommend screening for ... -
Studies of the immunopathogenesis of arthritis, with an emphasis on the alarmin HMGB1
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-20)Dysregulated inflammatory responses are characterized by the excessive release of endogenous inflammatory molecules, which initiate a chain of reactions, including immune cell infiltration, activation, polarization, necrosis, ... -
The T cell phenotype and receptor repertoire in different stages of rheumatoid arthritis : an immunological timeline
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-15)Rheumatoid arthritis (RA) is a systemic autoimmune disease, characterized by symmetrical inflammation in hands and feet. Antibodies recognizing citrullinated protein (ACPA) and/or rheumatoid factor (RF) are found in most ... -
Agnostic studies in epidemiology
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-24)In epidemiology there has been an consistent effort to construct refined methods aiming towards the ability to draw casual inference between an exposure and an outcome. This thesis, partly inspired by the genome-wide ...