Doktorsavhandlingar / Doctoral Theses - C2 (MBB): Recent submissions
Now showing items 181-200 of 308
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5-Lipoxygenase : studies on the active site iron, and on the stimulatory factors Ca2+ and ATP
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2000-09-13)Human 5-lipoxygenase (5LO) is a monomeric non-heme iron enzyme, which catalyses the first two steps in the biosynthesis of leukotrienes: oxygenation of arachidonic acid to yield 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicos ... -
Structural studies of saccharopine reductase and purple acid phosphatase
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2000-09-01)Lysine is synthesised in two different ways in living organisms, either by the diaminopimelate pathway or the [alpha]-aminoadipate pathway. These routes belong to the aspartate and the glutamate family of amino acid ... -
Characterization of novel glomerular proteins : role in physiology and disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-11-25)Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy. The costs for ... -
Structural and functional studies of proteins in cell signaling and cancer
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-11-20)Cancer is one of the most common causes of death in the western world. Cancer is an umbrella term for over 100 different diseases all caused by mutations in cells leading to uncontrolled cell division and metastasis. The ... -
A PDGFRalpha perspective on PDGF signalling in developmental and pathological processes
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-11-14)Platelet-derived growth factors PDGFs are a family of ligands and receptors that regulate multiple processes of paramount importance during embryonic development. They are also involved in several pathological events, ... -
Understanding inflammatory mechanisms in rheumatic diseases
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-11-05)Rheumatoid arthritis (RA), Psoriasis (Ps) and Psoriasis arthritis (PsA) are chronic inflammatory autoimmune disorders, where primary targets are peripheral joints, skin and skin/joints respectively. Both innate and adaptive ... -
Sequencing cancer
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-05-09)Cancer forms highly heterogeneous tissues at several molecular levels, genomic, proteomic, transcriptomic and other epigenetic traits. The level of complexity is further augmented by the dynamic nature of tumor progression ... -
Intricate aspects of the thioredoxin system in redox signaling
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-05-02)Reversible modifications of redox sensitive protein thiols by reactive oxygen and nitrogen species have emerged as a major posttranslational mechanism that affects the function of the respective proteins and therewith all ... -
The MHC and the recognition of self and altered self in experimental and rheumatoid arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-03-21)The Major histocompatibility complex (MHC) is a highly polymorphic and gene-dense region on chromosome 6 in humans and 20 in the rat. Genes in the MHC are the major risk factor for the development of autoimmunity. Rheumatoid ... -
Role of thioredoxin system in cell death caused by toxic compounds
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-02-17)Thioredoxin systems, comprising Trx, TrxR and NADPH, are one of the major disulfide reductase systems, which is crucial in maintaining cellular redox balance in mammalian cells. TrxR is a selenoprotein with a Sec residue ... -
Structural basis of cysteine biosynthesis and peptidoglycan remodelling in Mycobacterium tuberculosis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-12-12)Mycobacterium tuberculosis is the causative agent of tuberculosis, which is responsible for 1.3 million deaths annually. Treatment is difficult due to an elaborate defense machinery, which includes specific metabolic changes ... -
Calcium signaling in neurogenesis: regulation of proliferation, differentiation and migration of neural stem cells
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-11-21)The calcium ion (Ca2+) is a highly versatile and ubiquitous signaling messenger in all cell types. Signal transduction occurs through changes in the cytosolic Ca2+ concentration after the opening of Ca2+ channels in the ... -
Structural studies of enzymes regulating bacterial life style and cell wall biogenesis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-11-15)Bacteria can adapt to different biotic and abiotic environments by changing their life style, switching between sessile or motile, free-living or community-bound, virulent or dormant states. Each bacterium also faces the ... -
Structural studies of protein : protein complexes in the early secretory pathway
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-11-07)In this thesis, components of three different protein-protein complexes in the early secretory pathway have been studied by NMR spectroscopy and X-ray crystallography, with the aim of giving detailed structural information ... -
From single-cell transcriptomics to single-molecule counting
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-10-28)RNA-sequencing (RNA-seq) technology has been progressing so fast in the last few years and made it possible to perform transcriptome analysis at single-cell level that was even unimaginable a few years before. Nowadays, ... -
Mass spectrometry based investigation of Alzheimer’s disease and its biomarkers
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-09-04)The overall aim of this work was to find biomarkers for Alzheimer’s disease (AD) in such an easily accessible body fluid as blood and investigate the implications of these biomarkers for the AD mechanism. The central and ... -
Development and biomedical applications of highly sensitive enzyme activity assays of thioredoxin, thioredoxin reductase and glutaredoxin
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-05-23)Oxidative stress is implicated in the pathogenesis of many human diseases, thus it is interesting to study the relationship between antioxidants, the development and progression of diseases. The thioredoxin and glutaredoxin ... -
Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-05-13)The major histocompatibility complex (MHC) is an allele-rich and exceptionally gene dense region on human chromosome 6. Over 40% of the genes in this region have immune-related functions, including genes encoding MHCI and ... -
Characterization of novel genes of importance for renal glomerular function and disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-05-02)Glomerular kidney diseases are a major health care burden. The glomerular filtration barrier consists of three layers: the slit diaphragm that bridges the interlocking foot pro- cesses of the podocytes, the glomerular ... -
Autoantibody recognition of collagen type II in arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-03-13)Autoantibodies against collagen type II (CII), a protein localized in the joint cartilage, play a major role in collagen-induced arthritis (CIA), one of the most commonly used animal models for rheumatoid arthritis (RA). ...