Doktorsavhandlingar / Doctoral Theses - C2 (MBB): Recent submissions
Now showing items 201-220 of 308
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Structural and functional studies of class A scavenger receptors MARCO (SCARA2) and SCARA5
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-02-22)Our bodies are constantly exposed to various microorganisms and there is a constant battle between their survival and ours. Fortunately we are equipped with our immune system that takes remarkably good care of us, but when ... -
Bacterial thioredoxin systems as potential drug targets in novel antimicrobial therapies
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-02-08)Antimicrobial resistance is a big problem in modern medicine. One of the key components in the combat is the characterization of novel drug targets and the development of new classes of compounds targeting them. In the ... -
Genetic control of sensory neuron diversification
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-02-01)The somatosensory system of vertebrates transmits information from external and internal environments to the brain. This information relates to various modalities such as touch, temperature, itch and pain. The different ... -
Studies of the tumor-vasculature interface : role of TGF-beta 1-induced epithelial to mesenchymal transition
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2013-01-28)Tumor metastasis is a complex multistep process. Among key steps that occur during metastatic spread are acquisition of tumor cell motility, intravasation of tumor cells into blood or lymphatic vessels and extravasation ... -
Structural biology of carbohydrate transfer and modification in natural product biosynthesis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-12-10)Certain organisms, can during periods of limited resources, adapt their metabolism to enable biosynthesis of secondary metabolites, compounds that increase competitiveness and chances of survival. The subjects of this ... -
Genetic regulation of autoantibodies in arthritis : lessons from mouse models
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-11-08)Autoimmune diseases such as rheumatoid arthritis (RA) or multiple sclerosis (MS) are commonly regarded as complex or multifactorial diseases. This complexity regards to effector mechanisms involved in pathologic manifestations, ... -
Exploring the potential of antiangiogenic strategies targeting the TGF-β family in the tumor microenvironment
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-11-01)Members of the transforming growth factor (TGF)-β family exert their effect on virtually all cell types in the body, producing diverse and complex cellular responses. Additionally, TGF-β signaling is deregulated and ... -
Molecular mechanisms of amyloid self-regulation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-11-01)Amyloid is associated with both pathological protein deposits and the formation of functional protein structures. Therefore, several strategies have evolved to control the formation or inhibition of amyloid in vivo. In ... -
Expression and regulation of antimicrobial peptides in mucosal immunity
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-25)Antimicrobial polypeptides (AMPs) are effector molecules of the innate immune defense. AMPs are mainly expressed in epithelial cells and immune cells, providing the first line of defense to infection as direct antimicrobials. ... -
Chemoattractant receptors in drug discovery : FPR2 and CCR2-two potential targets
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-19)Chemoattractants and chemoattractant receptors have many important functions in multicellular organisms, not least for their role in regulating migration of leukocytes. The receptors are also involved in many pathologies ... -
The genetics of experimental arthritis in rodents
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-05)Unravelling the genetic susceptibility to complex autoimmune diseases and understanding these pathologies on a mechanistic level are major obstacles to improve our possibilities for therapeutic intervention and an increase ... -
Identification and characterization of kidney glomerulus-associated genes and proteins
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-07-06)The kidney glomerulus is a micro-organ comprised of a molecular filtration barrier that prevents the loss of blood proteins into the primary filtrate. This function is dependent on the coordination of its three constituent ... -
Characterization of novel podocyte proteins in the glomerular filtration barrier
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-05-08)The kidney is considered the most important organ of excretion eliminating the body from metabolic waste products. The nephron is the functional unit of the kidney, composed of a cluster of capillaries named glomerulus, ... -
Structural studies of the ERGIC-53/MCFD2 glycoprotein transport receptor complex
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-05-03)The secretory pathway defines and maintains the intracellular architecture of the eukaryotic cell. Proteins targeted to either the plasma membrane, the extracellular medium or to specific organelles within the cell are ... -
Role of antimicrobial peptides in combating shigellosis and in antibiotic-associated diarrhea
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-05-02)Antimicrobial peptides (AMPs) constitute front-line components of innate immunity in multicellular organisms. AMPs are able to kill a wide range of pathogens and exhibit additional important functions such as chemotaxis, ... -
Finding genes controlling arthritis in mice-Fcγ receptors and complement C5
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-04-26)Autoimmune diseases are dependent on multifactorial factors including genes, environment and interactions between them. This thesis is focused on a chronic inflammatory disorder, Rheumatoid arthritis (RA). So far only very ... -
Proteome studies, with emphasis on the kidney glomerulus
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-03-22)Proteomics aims to link genes to protein expression and function. Proteomics is a very versatile and technology-dependent discipline and the development of mass spectrometry-based proteomics has advanced the understanding ... -
Small talk in the tumor microenvironment : the contribution of fibroblasts and endothelial cells to the malignant phenotype
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2011-12-14)Cancer is the result of aberrant cells developing into tumor cells that act in concert with the micro- and macroenvironment like any other organ in our bodies. The cells and molecules of the tumor microenvironment are ... -
The role of macrophages in regulating inflammation by oxidative burst
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2011-11-16)The production of reactive oxygen species (ROS) through a process called oxidative burst is an essential defence mechanism against pathogens. In phagocytes, such as neutrophils and macrophages, the NADPH oxidase 2 (NOX2) ... -
Thioredoxin reductase as a target enzyme for electrophilic anticancer drugs
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2011-11-10)Induced production of reactive oxygen species (ROS) is a common attribute of most cancer cells. One strategy for cancer cells to maneuver the increased and potentially toxic levels of ROS is to induce the expression of ...