Artiklar / Articles - K1 (MMK): Recent submissions
Now showing items 21-40 of 91
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Association between laparoscopic antireflux surgery and recurrence of gastroesophageal reflux
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)IMPORTANCE: Cohort studies, mainly based on questionnaires and interviews, have reported high rates of reflux recurrence after antireflux surgery, which may have contributed to a decline in its use. Reflux recurrence ... -
Cohort profile : the Nordic antireflux surgery cohort (NordASCo)
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-06)PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having ... -
Gastrectomy compared to oesophagectomy for Siewert II and III gastro-oesophageal junctional cancer in relation to resection margins, lymphadenectomy and survival
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-12)It is unclear whether gastrectomy or oesophagectomy offer better outcomes for gastro-oesophageal junction (GOJ) cancer. A total of 240 patients undergoing total gastrectomy (n = 85) or oesophagectomy (n = 155) for Siewert ... -
Tenascin-C and fibronectin in normal esophageal mucosa, Barrett's esophagus, dysplasia and adenocarcinoma
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The ... -
Meta-analysis of health-related quality of life after minimally invasive versus open oesophagectomy for oesophageal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)BACKGROUND: The aim of this systematic review and meta-analysis was to compare health-related quality of life (HRQoL) outcomes between minimally invasive and open oesophagectomy for cancer at different postoperative time ... -
All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study)
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-11)OBJECTIVE: Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers. The aim of this study was ... -
Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loc
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm ... -
Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)Gastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include oesophagitis, ... -
Quality of life and psychological and gastrointestinal symptoms after cholecystectomy : a population-based cohort study
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)OBJECTIVE: The study aims to examine gastrointestinal symptoms, quality of life and the risk of psychological symptoms after cholecystectomy. DESIGN: This is a prospective population-based cohort study based on the ... -
Smoking cessation and risk of esophageal cancer by histological type : systematic review and meta-analysis
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-06)Smoking cessation is associated with a rapid and strong reduction in the risk of esophageal squamous cell carcinoma. The benefits of smoking cessation on esophageal squamous cell carcinoma are stronger in Western populations ... -
Health‑related quality of life after gastrectomy, esophagectomy, and combined esophagogastrectomy for gastroesophageal junction adenocarcinoma
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-09-04)BACKGROUND: The postoperative health-related quality of life (HRQOL) outcomes in patients with gastroesophageal junction (GEJ) adenocarcinoma after gastrectomy and esophagectomy are unclear. The aim was to evaluate HRQOL ... -
Are carriers of CYP21A2 mutations less vulnerable to psychological stress? A population-based national cohort study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)Background: Congenital adrenal hyperplasia (CAH) is one of the most common monogenic autosomal recessive disorders with an incidence of one in 15 000. About one in 70 individuals in the general population are carriers of ... -
Menopausal hormone therapy and the risk of esophageal and gastric cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-24)A protective effect of female sex hormones has been suggested to explain the male predominance in esophageal and gastric adenocarcinoma, but evidence is lacking. We aimed to test whether menopausal hormone therapy (MHT) ... -
The risk of mortality following secondary fundoplication in a population-based cohort study
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-16)BACKGROUND: Mortality following laparoscopic fundoplication has been found to be negligible. However, some patients require secondary fundoplication, and the risk of mortality following such procedure is scarcely ... -
Marital status, education, and income in relation to the risk of esophageal and gastric cancer by histological type and site
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-10)BACKGROUND: Marital status, income, and education might influence the risk of esophageal and gastric cancer, but the literature is limited. A large study addressing subtypes of these tumors was used to clarify these ... -
Helicobacter pylori eradication in the Swedish population
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-28)Objectives: Helicobacter pylori (H. pylori) is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a ... -
Eradication of Helicobacter pylori and gastric and oesophageal cancer : a systematic review and meta-analysis of cohort studies
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-28)Background: Helicobacter pylori (H. pylori) is associated with an increased risk of gastric adenocarcinoma and gastric mucosa associated lymphoid tissue (MALT) lymphoma, and a seemingly decreased risk of oesophageal ... -
Why oesophageal adenocarcinoma is occurring more frequently
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-28)Article in Dutch. The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important ... -
Intratumoral lactate metabolism in Barrett’s esophagus and adenocarcinoma
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-25)Background: Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are activated in various cancers, but their expression in ... -
Extent of lymphadenectomy and prognosis after esophageal cancer surgery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)IMPORTANCE: The prognostic role of the extent of lymphadenectomy during surgery for esophageal cancer is uncertain and requires clarification. OBJECTIVE: To clarify whether the number of removed lymph nodes influences ...