Inst för medicin, Solna / Dept of Medicine, Solna: Recent submissions
Now showing items 1-20 of 802
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Role of non-cardiac comorbidities in heart failure across the ejection fraction spectrum : diagnosis, treatment and prognosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-08-09)Background. Heart failure (HF) represents a significant challenge due to its heterogeneous nature across the spectrum of ejection fraction (EF). This heterogeneity is in part characterized by a difference in distribution ... -
Antibiotics in pregnancy : utilization, determinants and safety
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-22)Antibiotics are indispensable in maternal health. Crucial for treating and preventing bacterial infections ranging from common ailments to life-threatening conditions, antibiotics are inevitably prescribed to pregnant women ... -
Fibrotic lung disease : early signs, treatment and outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-21)Idiopathic pulmonary fibrosis (IPF) has gained a lot of attention by the research community in recent decades. Thanks to enhanced understanding on pathophysiological mechanisms behind the fibrosing process together with ... -
From autoimmunity to inflamed joints : study of risk factors, mediators and cellular targets in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-24)Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting mainly the joints and leading to disability. Circulating antibodies against citrullinated proteins (ACPA) are present in the majority of patients and are ... -
Novel diagnostic and prognostic tools in infiltrative cardiomyopathy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-16)Background: Heart failure is a severe medical condition, increasingly common in the aging population, causing both vast morbidity and mortality. Amongst different etiologies of heart failure, infiltrative cardiomyopathies ... -
From vaccination to infection : mechanistic studies of immune responses to SARS-CoV-2
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-04)The emergence of a novel coronavirus, SARS-CoV-2, sparked a global health crisis, leading to the COVID-19 pandemic. Development and deployment of vaccines against COVID-19 elevated population-level immunity and reduced ... -
Physiological and lifestyle-related cardiovascular risk factors for vessels, ventricle, and valve
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-03)Cardiovascular diseases are the most common cause of mortality globally, claiming twice as many lives as cancer and more than all nutritional disorders, infectious diseases, and maternal/neonatal conditions combined. The ... -
Heart failure with preserved and reduced ejection fraction : comorbidities, therapies and cause-specific outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-27)Background: Heart failure (HF) is associated with worse prognosis and poor quality of life, and its rising global prevalence puts a growing strain on healthcare systems. While most previous studies have focused on ... -
Diabetes, cardiovascular events, and lifestyle : from epidemiology to clinic
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-15)Today, the health care system plays an important role in the prevention of diseases, not least through support of a healthy lifestyle, including being physically active. Given the development of digital tools together with ... -
Gestational weight gain, bariatric surgery, and adverse maternal and infant outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-20)Gestational weight gain is a crucial predictor for various adverse maternal and infant outcomes. In 2009, the U.S. Institute of Medicine (IOM) introduced optimal ranges for gestational weight gain based on a woman's ... -
Prognostication in heart failure across the ejection fraction spectrum : implications for clinical practice and trial design
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-19)Background. The heterogeneity of heart failure (HF) across the ejection fraction (EF) spectrum presents a challenge when triaging for follow-up, implementing therapies, and designing trials. There is a preconceived notion ... -
Reproductive and lifestyle risk factors for sarcoidosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-14)Sarcoidosis is a systemic inflammatory condition with an unknown origin, characterized by the formation of granulomatous lesions primarily in the lungs and lymphatic system. Despite over a century since it was first ... -
Understanding juvenile idiopathic arthritis : a multidimensional approach
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-25)The overarching objective of this doctoral thesis is to enhance the understanding of Juvenile Idiopathic Arthritis (JIA), a complex autoimmune disease affecting children. With the aim of filling the knowledge gaps in JIA, ... -
Monitoring of the oral anticoagulants apixaban and rivaroxaban to optimize individual safety and efficacy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-25)The oral anticoagulants apixaban and rivaroxaban are administered at fixed doses without requiring routine monitoring. However, there is a dose and exposure dependency in efficacy and safety, and monitoring the anticoagulants ... -
Comorbidities in early rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-23)All of the studies that form part of this thesis concern the subject of comorbid conditions in early rheumatoid arthritis (RA). We have used linkage of Swedish clinical and demographic registers as well as the Swedish ... -
The dimensions of human and murine CD8 T lymphocyte diversity
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-12)The adaptive immune system generates and maintains a pool of CD8+ T cells with an almost limitless specificity with the purpose of maintaining homeostasis. Upon antigen encounter, CD8+ T cells undergo functional diversification ... -
Idiopathic inflammatory myopathies and cancer : familial risk, genetics and consequences
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-02)Idiopathic inflammatory myopathies (IIMs) are a group of rare rheumatic inflammatory diseases (RIDs), characterised by a diverse range of clinical, serological and histopathological characteristics, with muscle weakness ... -
From oral infection to autoimmunity : studies of antibodies and B cells on the path towards rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-12-08)Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial joints, which can lead to irreversible joint destruction and disability if not treated properly. The majority ... -
A study of immune dynamics in experimental arthritis using CRISPR and PET techniques
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-11-17)Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation associated with CD4 T cell dysfunction. The disease has no cure; thus, early diagnosis and interventions are crucial. DNMT3A ... -
Atopic dermatitis and distress
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-11-10)Atopic dermatitis (AD) is a chronic, inflammatory skin condition characterized by itching, redness, and skin lesions, affecting approximately 10–20% of children and 1–3% of adults worldwide. Distress associated with AD can ...