Doktorsavhandlingar / Doctoral Theses - C2 (MBB): Recent submissions
Now showing items 101-120 of 308
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Role of platelet-derived growth factor B in cholesterol and glucose metabolism
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-12-15)Platelet-derived growth factor (PDGFB) is a critical molecule for recruiting pericytes. Due to the fundamental role of the pericytes in angiogenesis and vascular stability, PDGFB knockout mice die perinatally from severe ... -
Mechanisms controlling midbrain dopaminergic neuron development
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-11-25)The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated ... -
Origin of life : testing the isotopic resonance hypothesis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-11-09)The Miller-Urey (MU) experiment provided evidence supporting the abiogenesis theory, and is considered to be the seminal experiment in the context of origin of life. The MU mixture produced in the experiment is assumed to ... -
Positional identification and functional analysis of genes regulating autoimmune arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-11-07)The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA). However, even the ... -
Exploiting nucleotide metabolism to improve cancer therapy : by targeting dUTPase, dCTPase and NUDT15
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-10-28)Synthetic nucleobase- and nucleoside-analogs have stood the test of time and remain a cornerstone in the treatment regimen against various forms of cancer. Due to their resemblance to endogenous nucleotides these antimetabolites ... -
Neonatal screening in Sweden and disease-causing variants in phenylketonuria, galactosaemia and biotinidase deficiency
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-10-25)Phenylketonuria, galactosaemia and biotinidase deficiency were the first three inborn errors of metabolism to be included in the Swedish programme. This thesis describes these conditions with an emphasis on screening ... -
Neuronal types and their specification dynamics in the autonomic nervous system
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-10-07)The autonomic nervous system is formed by a sympathetic and a parasympathetic division that have complementary roles in the maintenance of body homeostasis. Autonomic neurons, also known as visceral motor neurons, are ... -
Mechanism of enzymes involved in leukotriene C4 biosynthesis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-09-06)Cysteinyl leukotrienes (cys-LTs) are potent proinflammatory mediators associated with various diseases including asthma and allergic rhinitis. Leukotriene C4 synthase (LTC4S) and microsomal glutathione transferase 2 ... -
Putting the pieces together : elucidation of podocyte biology in the homeostasis of the kidney filtration barrier
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-08-25)End-stage renal disease (ESRD) is a devastating condition that can only be treated with chronic dialysis or kidney transplantation. ESRD treatment costs account for up to 10% of healthcare budgets in the Western world. ... -
Cross-tissue regulatory gene networks in coronary atherosclerosis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-08-17)Coronary artery disease (CAD) is the underlying cause of myocardial infarction and stroke that together are responsible for nearly 30% of all global deaths. CAD is a common complex disease caused by the interactions of ... -
Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-08-10)Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and ... -
Exploring the role of PDGF-D in health and disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-06-01)The platelet-derived growth factors (PDGF) and their receptors (PDGFRs) regulate growth and migration in cell populations of mesenchymal origin. The PDGF signaling system is vital for development, in neural crest formation, ... -
Establishing a proteomics-based monocyte assay to assess differential innate immune responses
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-05-23)The innate immune system represents the first line of organism defense. Monocytes and their derivatives, the macrophages, play a central role in this response. The monocyte response to various stimuli is complex and includes ... -
eQTL mapping and inherited risk enrichment analysis : a systems biology approach for coronary artery disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-05-02)Despite extensive research during the last decades, coronary artery disease (CAD) remains the number one cause of death, responsible for near 50% of global mortal- ity. A main reason for this is that CAD has a complex ... -
Structural studies of glycoprotein sorting and processing complexes in the early secretory pathway
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-03-18)The secretory pathway of a eukaryotic cell exerts a stringently regulated quality control system for the correct folding and transport of newly synthesised proteins and their subsequent transfer to their final destinations. ... -
Counting molecules in cell-free DNA and single cells RNA
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-03-08)The field of Molecular Biology got started in earnest with the discovery of the molecular structure of DNA. This lead to a surge of interest into the relationships between DNA, RNA and proteins, and to the development of ... -
Characterization of thioredoxin related protein of 14 kDa and its role in redox signaling
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-02-22)Reversible reduction/oxidation (redox) reactions play key roles in cellular signaling pathways. Particularly cysteine residues in proteins can be modified by reactive oxygen-, nitrogen- or sulfur species (ROS, RNS, RSS), ... -
Vascular endothelial growth factor B-role in metabolism, lipotoxicity and disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2015-12-14)Vascular Endothelial Growth Factor B (VEGF-B) was previously shown to control lipid uptake from the bloodstream via the endothelium into tissue cells, and when ablating Vegfb, intra-tissue lipid accumulation was reduced. ... -
Structural and functional studies of L-PGDS and SMPDL3A, enzymes in lipid signaling family
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2015-11-30)Enzymes are indispensable in maintaining the biological system. They metabolize complex molecules to supply nutrients, to produce energy, to regulate transcription of gene expression, and to control the concentration of ... -
Exploring novel roles of tumor pericytes
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2015-11-19)Tumor biology has been extensively studied over the last few decades, with a principal focus on how neoplastic cells obtain cellular immortality. A number of oncogenes and tumor suppressor genes have been uncovered that ...