Avhandlingar / Theses: Recent submissions
Now showing items 1-20 of 9612
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Autoimmune pancreatitis : from bench to bedside
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-08-30)Background: Decreased microbial diversity had been associated with the establishment of an environment in which pathogens could incite and sustain chronic inflammation. Metabolomic analysis of fecal samples provides insights ... -
Unveiling mechanisms of translational control in disease
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-08-29)mRNA translation is a core cellular function that enables rapid alterations in proteome as a response to intra- or extracellular stimuli, with or without the corresponding changes in the transcriptome. Considering its ... -
Mitochondrial ß-oxidation disorders : from screening to diagnosis, fasting metabolism and optimized treatment
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-08-29)Mitochondrial beta-oxidation disorders are a group of recessive diseases characterized by fasting intolerance and symptoms ranging from intermittent myalgia and rhabdomyolysis to cardiomyopathy and severe hypoketotic ... -
Brain development and response to injury : focus on microglia and cranial irradiation
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-08-28)Postnatal brain development is crucial for proper brain formation and function in adulthood. Impairment of this process due to external insults such as cranial radiotherapy, used to treat brain tumors and metastases, can ... -
Physical activity and mental health among trauma-affected refugees : associations, experiences, and intervention efficacy
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-08-27)Aims: The overall aim of this thesis was to increase the understanding of physical activity (PA) and its impact on mental health and wellbeing among trauma-affected refugees and asylum-seekers, and with a particular focus ... -
Risk factors and prognosis of diabetes with and without an autoimmune component
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-08-26)Diabetes is heterogenous and encompasses different types such as type 1 diabetes (T1D), type 2 diabetes (T2D), and latent autoimmune diabetes in adults (LADA), which shares clinical characteristics with T2D and genetic ... -
Parents with ADHD : parenting, stress, and interventions
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-08-23)Objective: In the project that forms the basis of this thesis, we wanted to: test the psychometric properties of the Parental Stress Scale (PSS) translated into Swedish (Study I); examine whether the feasibility and effect ... -
Microglia : guardians across the lifespan and disease spectrum
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-08-23)Microglia, the resident immune cells of the central nervous system, are crucial for maintaining homeostasis and responding to injury and disease. In this thesis, I aim to elucidate the molecular diversity and regulatory ... -
Safety nets and tailored support : developing complex social protection interventions for tuberculosis-affected families in Vietnam
(Inst för global folkhälsa / Dept of Global Public Health, 2024-08-23)Background: Tuberculosis (TB) is an infectious disease that although treatable and curable, continues to kill an estimated 1.3 million people per year. The disease disproportionally affects the most vulnerable people in a ... -
Hemiplegic cerebral palsy : clinical presentation and aetiology
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-08-21)Cerebral palsy is an umbrella term for motor impairments that share features of a non-progressive brain injury, acquired during the early stages of its development. These motor impairments can have different aetiologic ... -
Strategies for expanding organ availability and improving transplant outcomes
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-08-20)Organ transplantation is a lifesaving treatment for patients suffering from end stage liver disease or heart failure. For patients with chronic kidney disease, transplantation reduces morbidity and decreases mortality. ... -
Enantiomeric pharmacokinetics of methylphenidate and processing speed measures in adults with ADHD and substance use disorders
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-08-20)The overall aim of this thesis was to investigate the interindividual variability in the enantioselective pharmacokinetics of methylphenidate (MPH) in healthy adults as well as in adults with attention deficit hyperactivity ... -
Functional characterization of protective antibodies in murine models of rheumatoid arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-20)Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease, characterized by chronic, erosive polyarthritis and by the presence of various autoantibodies in serum and synovial fluid. There are many different ... -
Pathogenic mitochondrial DNA point mutations in the immune system : ‘A tale of two cities’
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-20)Study I: The Effects of High Heteroplasmic Pathogenic mt-tRNA Mutations on Immunity. High levels of heteroplasmic pathogenic mtDNA mutations in mitochondrial tRNA (mt-tRNA) genes can severely disrupt mitochondrial translation ... -
Genome and prognosis models : towards the personalized therapy for patients with B-cell lymphoma
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-19)B-cell lymphoma is a heterogeneous cancer derived from B lymphocytes, with over 60 subtypes classified by the World Health Organization (WHO). Common subtypes include diffuse large B-cell lymphoma (DLBCL), follicular ... -
Angiogenesis in ocular neovascular diseases : from multitarget inhibition to gene therapy tools
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-08-16)Ocular neovascular diseases, such as neovascular age-related macular degeneration (nAMD) or proliferative retinopathies (PRs) are characterized by the growth of abnormal blood vessels in the eye, leading to vision impairment. ... -
Unravelling host-bacterial interactions using tissue microbiology approaches
(Inst för neurovetenskap / Dept of Neuroscience, 2024-08-16)To fully grasp the complexity of host-pathogen interactions, there is a pressing need for more advanced and comprehensive infection models. Infections can occur at various sites within the body, each with its own unique ... -
Post-migration and stigma-based factors influencing mental health among refugees and sexual minority migrants
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-08-16)This thesis investigated how experiences in the new country of residence influence mental health among two subgroups among migrants that have been shown to be at heightened risk of developing poor mental health: refugees ... -
Dynamics of transcriptomic and epigenomic states in mouse and human central nervous system cells in multiple sclerosis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-12)Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by immunologically mediated demyelination in the central nervous system (CNS). Oligodendrocytes, a type of glial cell in the CNS, are responsible for ... -
Mechanisms controlling the latent HIV-1 provirus
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-08-09)HIV is incurable due the persistence of latent but replication competent HIV proviruses. Lifelong antiretroviral therapy (ART) stops HIV progression to AIDS with minimal side effects. However, a HIV cure has only been ...