Lung-function trajectories : relevance and implementation in clinical practice
Author: Melén, Erik; Faner, Rosa; Allinson, James P; Bui, Dinh; Bush, Andrew; Custovic, Adnan; Garcia-Aymerich, Judith; Guerra, Stefano; Breyer-Kohansal, Robab; Hallberg, Jenny; Lahousse, Lies; Martinez, Fernando D; Merid, Simon Kebede; Powell, Pippa; Pinnock, Hilary; Stanojevic, Sanja; Vanfleteren, Lowie E G W; Wang, Gang; Dharmage, Shyamali C; Wedzicha, Jadwiga; Agusti, Alvar; Melén, Erik
Department: Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset
View/ Open:
Manuscript and figures (977.8Kb)
Abstract
Lung development starts in utero and continues during childhood through to adolescence, reaching its peak in early adulthood. This growth is followed by gradual decline due to physiological lung ageing. Lung-function development can be altered by several host and environmental factors during the life course. As a result, a range of lung-function trajectories exist in the population. Below average trajectories are associated with respiratory, cardiovascular, metabolic, and mental health comorbidities, as well as with premature death. This Review presents progressive research into lung-function trajectories and assists the implementation of this knowledge in clinical practice as an innovative approach to detect poor lung health early, monitor respiratory disease progression, and promote lung health. Specifically, we propose that, similar to paediatric height and weight charts used globally to monitor children's growth, lung-function charts could be used for both children and adults to monitor lung health status across the life course. To achieve this proposal, we introduce our free online Lung Function Tracker tool. Finally, we discuss challenges and opportunities for effective implementation of the trajectory concept at population level and outline an agenda for crucial research needed to support such implementation.
Institution:
- Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet and Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden
- University of Barcelona, FCRB-IDIBAPS, CIBERES, Barcelona, Spain
- National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
- Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia
- ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain
- Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA
- Department of Respiratory and Pulmonary Diseases and Ludwig Boltzmann Institute for Lung Health, Clinic Hietzing, Vienna, Austria
- Ghent University, Ghent, Belgium
- European Lung Foundation, Sheffield, UK
- Usher Institute, University of Edinburgh, Edinburgh, UK
- Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada
- COPD Center, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Sichuan, China
- Respiratory Institute, Clinic Barcelona, Cathedra Salud Respiratoria-University of Barcelona, CIBERES, Barcelona, Spain
Citation: Lancet. 2024 Apr 13;403(10435):1494-1503.
Citation DOI: 10.1016/S0140-6736(24)00016-3
Citation PMID: 38490231
Citation ISI: 001229360600001
Publishing journal: Lancet (London, England)
Eprint status: Peer Reviewed
Version: Accepted
Issue date: 2024-08-09
Sponsorship:
- European Respiratory Society
- AstraZeneca
- Chiesi
- GlaxoSmithKline
- Menarini Group
- Sanofi
Rights:
Article is made available in accordance with the publisher's policy and may be subject to copyright law. Please refer to the publisher's site for terms of use.
Publication year: 2024
Statistics
Total Visits
Views | |
---|---|
Lung-function ... | 34 |
Total Visits Per Month
March 2024 | April 2024 | May 2024 | June 2024 | July 2024 | August 2024 | September 2024 | |
---|---|---|---|---|---|---|---|
Lung-function ... | 0 | 0 | 0 | 0 | 0 | 28 | 6 |
File Visits
Views | |
---|---|
Trajectory expert opinion CADSET accepted version The Lancet 2024.pdf | 6 |
Top country views
Views | |
---|---|
United States | 9 |
Ireland | 6 |
Australia | 2 |
Norway | 2 |
Bulgaria | 1 |
China | 1 |
Germany | 1 |
Japan | 1 |
Latvia | 1 |
Sweden | 1 |
Top cities views
Views | |
---|---|
Dublin | 2 |
Ashburn | 1 |
Düsseldorf | 1 |
Merrylands | 1 |
Singapore | 1 |
Skaerhamn | 1 |
Sofia | 1 |