Structural and neurohormonal factors in left ventricular hypertrophy and inhibition of the renin-angiotensin-aldosterone system
Author: Malmqvist, Karin
Date: 2002-04-19
Location: Aulan, plan 3, Danderyds Sjukhus
Time: 13.00
Department: Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital
Abstract
Hypertensive left ventricular hypertrophy (LVH) is a major risk factor
for cardiovascular morbidity and mortality. The aim of this thesis was to
study how different neurohormonal systems relate to left ventricular
mass, and to study structural and functional cardiovascular changes in
hypertensive LVH. Furthermore to evaluate how inhibition of the renin-
angiotensin-aldosterone system (RA-AS) influences cardiovascular changes.
Two different hypertensive populations were studied. One relatively large
group of hypertensive patients with echocardiographic verified LVH, who
were treated with AT1- receptor blockade or beta-receptor blockade for
one year. The other group consisted of never treated non-diabetic
hypertensive patients, and were treated with an ACE inhibitor or a
beta-receptor blocker for one year.
Increased left ventricle mass was related to determinants of RAAS. Both
AT,receptor blockade and inhibition of ACE, reduced left ventricular mass
more than beta-receptor blockade did, at same level of blood pressure
lowering. This suggests that RAAS plays an important role in the
development and maintenance of LVH, beyond its effect on blood pressure
control. In contrast, insulin, proinsulin, insulin sensitivity (assessed
by euglycemic clamp technique) and leptin, were not related to left
ventricular mass, when body size was accounted for. Neither were plasma
and urine catecholamines related to LVH. Our results do not support that
insulin, leptin or sympathetic nervous system have direct myocardial
growth stimulating effects, although these neurohormonal systems may have
peripheral effects that promote the development of LVH.
Prolonged QT dispersion, which indicates cardiac electric instability,
related to LVH. AT, -receptor blockade, but not beta-receptor blockade,
reduced QT dispersion, as well as repolarisation time, independently of
changes in left ventricular mass, blood pressure, or heart rate. This
suggests that inhibition of RAAS may induce structural and electrical
remodeling in a direction that could decrease the risk of malignant
arrhythmias in hypertensive patients.
Patients with increased relative left ventricular wall thickness
(concentric LW), who are at higher risk of future cardiovascular events,
displayed elevated levels of soluble cell adhesion molecules, markers of
endothelium dysfunction. Thus, our results may indicate an association
between more advanced hypertensive heart disease and vascular
alterations. Interestingly, E-selectin was related to aldosterone.
Thus, we suggest that RAAS plays an important role for development and
maintenance of structural and functional cardiovascular changes, and
blockade of the AT, -receptor may improve cardiac function and possibly
prognosis in hypertensive LVH.
List of papers:
I. Malmqvist K, Ohman KP, Lind L, Nystrom F, Kahan T (2002). "The importance of the renin- angiotensin system, sympathetic function, insulin and leptin for left ventricular mass in hypertension." (Submitted)
II. Malmqvist K, Isaksson H, Ostergren J, Kahan T (2001). "Left ventricular mass is not related to insulin sensitivity in never-treated primary hypertension. " J Hypertens 19(2): 311-7
Pubmed
III. Malmqvist K, Kahan T, Edner M, Held C, Hagg A, Lind L, Muller-Brunotte R, Nystrom F, Ohman KP, Osbakken MD, Ostergern J (2001). "Regression of left ventricular hypertrophy in human hypertension with irbesartan. " J Hypertens 19(6): 1167-76
Pubmed
IV. Malmqvist K, Ohman KP, Lind L, Nystrom F, Kahan T (2002). "Long term effects of irbesartan and atenolol on the renin-angiotensin system, sympathetic nervous system, insulin and leptin in hypertension." (Submitted)
V. Malmqvist K, Kahan T, Isaksson H, Ostergren J (2001). "Regression of left ventricular mass with captopril and metoprolol, and the effects on glucose and lipid metabolism. " Blood Press 10(2): 101-10
Pubmed
VI. Malmqvist K, Kahan T, Edner M, Bergfeldt L (2002). "Different actions of irbesartan and atenolol cardiac repolarization in hypertensive left ventricular hypertrophy." (Submitted)
I. Malmqvist K, Ohman KP, Lind L, Nystrom F, Kahan T (2002). "The importance of the renin- angiotensin system, sympathetic function, insulin and leptin for left ventricular mass in hypertension." (Submitted)
II. Malmqvist K, Isaksson H, Ostergren J, Kahan T (2001). "Left ventricular mass is not related to insulin sensitivity in never-treated primary hypertension. " J Hypertens 19(2): 311-7
Pubmed
III. Malmqvist K, Kahan T, Edner M, Held C, Hagg A, Lind L, Muller-Brunotte R, Nystrom F, Ohman KP, Osbakken MD, Ostergern J (2001). "Regression of left ventricular hypertrophy in human hypertension with irbesartan. " J Hypertens 19(6): 1167-76
Pubmed
IV. Malmqvist K, Ohman KP, Lind L, Nystrom F, Kahan T (2002). "Long term effects of irbesartan and atenolol on the renin-angiotensin system, sympathetic nervous system, insulin and leptin in hypertension." (Submitted)
V. Malmqvist K, Kahan T, Isaksson H, Ostergren J (2001). "Regression of left ventricular mass with captopril and metoprolol, and the effects on glucose and lipid metabolism. " Blood Press 10(2): 101-10
Pubmed
VI. Malmqvist K, Kahan T, Edner M, Bergfeldt L (2002). "Different actions of irbesartan and atenolol cardiac repolarization in hypertensive left ventricular hypertrophy." (Submitted)
Issue date: 2002-03-29
Publication year: 2002
ISBN: 91-628-4879-8
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