The roots of autism and ADHD twin study in Sweden (RATSS)
Author: Bölte, Sven; Willfors, Charlotte; Berggren, Steve; Norberg, Joakim; Poltrago, Lina; Mevel, Katell; Coco, Christina; Fransson, Peter; Borg, Jacqueline; Rouslan, Sitnikov; Toro, Roberto; Tammimies, Kristiina; Anderlid, Britt-Marie; Nordgren, Ann; Falk, Anna; Meyer, Urs; Kere, Juha; Landén, Mikael; Dalman, Christina; Ronald, Angelica; Anckarsäter, Henrik; Lichtenstein, Paul
Department: Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics
View/ Open:
Author Accepted Manuscript (292.0Kb)
Abstract
Neurodevelopmental disorders affect a substantial minority of the general population. Their origins are still largely unknown, but a complex interplay of genetic and environmental factors causing disturbances of the central nervous system's maturation and a variety of higher cognitive skills is presumed. Only limited research of rather small sample size and narrow scope has been conducted in neurodevelopmental disorders using a twin-differences design.
The Roots of Autism and ADHD Twin Study in Sweden (RATSS) is an ongoing project targeting monozygotic twins discordant for categorical or dimensional autistic and inattentive/hyperactive-impulsive phenotypes as well as other neurodevelopmental disorders, and typically developing twin controls. Included pairs are 9 years of age or older, and comprehensively assessed for psychopathology, medical history, neuropsychology, and dysmorphology, as well as structural, functional, and molecular brain imaging. Specimens are collected for induced pluripotent (iPS) and neuroepithelial stem cells, genetic, gut bacteria, protein-/monoamine, and electron microscopy analyses. RATSS's objective is to generate a launch pad for novel surveys to understand the complexity of genotype-environment-phenotype interactions in autism spectrum disorder and attention-deficit hyperactivity disorder (ADHD). By October 2013, RATSS had collected data from 55 twin pairs, among them 10 monozygotic pairs discordant for autism spectrum disorder, seven for ADHD, and four for other neurodevelopmental disorders.
This article describes the design, recruitment, data collection, measures, collected pairs' characteristics, as well as ongoing and planned analyses in RATSS. Potential gains of the study comprise the identification of environmentally mediated biomarkers, the emergence of candidates for drug development, translational modeling, and new leads for prevention of incapacitating outcomes.
The Roots of Autism and ADHD Twin Study in Sweden (RATSS) is an ongoing project targeting monozygotic twins discordant for categorical or dimensional autistic and inattentive/hyperactive-impulsive phenotypes as well as other neurodevelopmental disorders, and typically developing twin controls. Included pairs are 9 years of age or older, and comprehensively assessed for psychopathology, medical history, neuropsychology, and dysmorphology, as well as structural, functional, and molecular brain imaging. Specimens are collected for induced pluripotent (iPS) and neuroepithelial stem cells, genetic, gut bacteria, protein-/monoamine, and electron microscopy analyses. RATSS's objective is to generate a launch pad for novel surveys to understand the complexity of genotype-environment-phenotype interactions in autism spectrum disorder and attention-deficit hyperactivity disorder (ADHD). By October 2013, RATSS had collected data from 55 twin pairs, among them 10 monozygotic pairs discordant for autism spectrum disorder, seven for ADHD, and four for other neurodevelopmental disorders.
This article describes the design, recruitment, data collection, measures, collected pairs' characteristics, as well as ongoing and planned analyses in RATSS. Potential gains of the study comprise the identification of environmentally mediated biomarkers, the emergence of candidates for drug development, translational modeling, and new leads for prevention of incapacitating outcomes.
Institution:
- Center of Neurodevelopmental Disorders at Karolinska Institutet, Stockholm, Sweden
- Pediatric Neuropsychiatry Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
- MRI Research Center, Neuroradiology Clinic, Karolinska University Hospital, Stockholm, Sweden
- Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
- Physiology and Behavior Laboratory, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland
- Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
- Section of Psychiatry and Neurochemistry, Sahlgrenska Academy, Gothenburg, Sweden
- Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
- Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, UK
- Neuroscience and Physiology, Forensic Psychiatry, University of Gothenburg, Gothenburg, Sweden
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Citation: Twin Res Hum Genet. 2014 Jun;17(3):164-76.
Citation DOI: 10.1017/thg.2014.12
Citation PMID: 24735654
Citation ISI: 000337259200003
Publishing journal: Twin Research and Human Genetics
Eprint status: Peer Reviewed
Version: Accepted
Issue date: 2014-06-25
Sponsorship:
- Swedish Research Council
- Swedish Research Council in partnership with Fas, Formas and Vinnova, 259-2012-24
- Innovative Medicines Initiative Joint Undertaking, 115300
- EU's Seventh Framework Programme, FP7/2007-2013
- EFPIA companies
- Stockholm County Council
- Sällskapet Barnavård
- Swedish Order of Freemasons Grand Loge Stockholm
- Stiftelsen Sunnerdahls Handikappfond
- Hjärnfonden
- Autism and Asperger Society Stockholm
- Tore Nilssons Stiftelsen
- Jeanssons Stiftelse
- Magnus Bergvalls Stiftelse
- PRIMA Barn- och Vuxenpsykiatri
Rights:
CC BY-NC-ND 4.0
Publication year: 2014
Statistics
Total Visits
Views | |
---|---|
The ...(legacy) | 939 |
The ... | 334 |
Total Visits Per Month
March 2024 | April 2024 | May 2024 | June 2024 | July 2024 | August 2024 | September 2024 | |
---|---|---|---|---|---|---|---|
The ... | 2 | 5 | 7 | 4 | 1 | 6 | 5 |
File Visits
Views | |
---|---|
10.1017_thg.2014.12.pdf(legacy) | 830 |
10.1017_thg.2014.12.pdf | 451 |
AAM_The roots of autism and ADHD.pdf | 77 |
Bölte etal_RATSS_TRHG 131112.pdf(legacy) | 6 |
Top country views
Views | |
---|---|
United States | 382 |
Sweden | 270 |
China | 129 |
Germany | 70 |
Finland | 19 |
Russia | 19 |
Ireland | 15 |
South Korea | 15 |
United Kingdom | 14 |
France | 12 |
Top cities views
Views | |
---|---|
Ashburn | 77 |
Sunnyvale | 60 |
Stockholm | 43 |
Beijing | 36 |
Shenzhen | 24 |
Kiez | 23 |
Bagarmossen | 14 |
Dublin | 14 |
Seoul | 11 |
Umeå | 11 |