The Swedish Twin Registry : establishment of a biobank and other recent developments
Author: Magnusson, Patrik K E; Almqvist, Catarina; Rahman, Iffat; Ganna, Andrea; Viktorin, Alexander; Walum, Hasse; Halldner, Linda; Lundström, Sebastian; Ullén, Fredrik; Långström, Niklas; Larsson, Henrik; Nyman, Anastasia; Hellner Gumpert, Clara; Råstam, Maria; Anckarsäter, Henrik; Cnattingius, Sven; Johannesson, Magnus; Ingelsson, Erik; Klareskog, Lars; de Faire, Ulf; Pedersen, Nancy L; Lichtenstein, Paul
Department: Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics
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Abstract
The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.
Institution:
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden
- Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
- Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden
- CELAM (Center for Ethics, Law and Mental Health), University of Gothenburg, Gothenburg, Sweden
- Swedish Prison and Probation Service, R&D Unit, Norrköping, Sweden
- Gillberg Neuropsychiatry Centre, Institution of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
- Centre for Psychiatry Research & Education, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
- Department of Clinical Sciences, Lund University, Lund, Sweden
- Unit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
- Department of Economics, Stockholm School of Economics, Stockholm, Sweden
- Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
- Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Citation: Twin Res Hum Genet. 2013 Feb;16(1):317-29.
Citation DOI: 10.1017/thg.2012.104
Citation PMID: 23137839
Citation ISI: 000314799700048
Publishing journal: Twin Research and Human Genetics
Eprint status: Peer Reviewed
Version: Accepted
Issue date: 2013-12-20
Sponsorship:
- Swedish Research Council, M-2005-1112, 20113060, K2006-71X-14676-04-2, 2008-54x20638-01-3
- GenomEUtwin, EU/QLRT-2001-01254, QLG2-CT-2002-01254
- National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U01-066134
- Swedish Foundation for Strategic Research (SSF)
- Heart and Lung foundation, 20070481
- Strategic Research Program in Epidemiology at Karolinska Institutet
- Swedish Asthma and Allergy Association
- Regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet (ALF)
- Swedish Council for Working Life and Social Research (Forte), 2004-0174, 2007-0231
- Systembolaget
- National Board of Forensic Medicine
- Swedish Prison and Probation Service
- Bank of Sweden Tercentenary Foundation
- Söderström-Königska foundation
- Karolinska Institutet Center of Neurodevelopmental Disorders (KIND)
- Swedish Cancer Society, 4594-B01-01XAC, 4594-B04-04XAB
- EU Network of Excellence Lifespan, FP6 036894
Rights:
CC BY-NC-ND 4.0
Publication year: 2013
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