Artiklar / Articles - K7 (OnkPat): Recent submissions
Now showing items 21-39 of 39
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Small-molecule inhibitors of the receptor tyrosine kinases : promising tools for targeted cancer therapies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-08-11)Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. This represents a ... -
Comparative expression profile of orphan receptor tyrosine kinase ROR1 in Iranian patients with lymphoid and myeloid leukemias
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-05-28)It has recently been shown that ROR1, a member of the receptor tyrosine kinase family, is overexpressed in leukemic B cells of Chronic Lymphocytic Leukemia (CLL) and a subset of Acute Lymphoblastic Leukemia (ALL). In this ... -
Ligation of human Fc receptor like-2 (FCRL2) by monoclonal antibodies downregulates B cell receptor mediated signaling
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-05-27)B cell antigen receptor (BCR) signaling and its regulation through negative and positive regulators are critical for balancing B cell response and function. Human Fc receptor like-2 (FCRL2), a member of the newly identified ... -
Frequency analysis of HLA class I alleles in Iranian patients with progressive and non-progressive chronic lymphocytic leukemia
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-12-17)Chronic lymphocytic leukemia (CLL) is a malignant disorder of B cell origin, with low incidence in Asian populations. In this study we investigated the HLA-class I A and B allele frequencies in 87 Iranian CLL patients and ... -
The tyrosine kinase receptor ROR1 is constitutively phosphorylated in chronic lymphocytic leukemia (CLL) cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-10-30)Phosphorylation of receptor tyrosine kinases (RTKs) has a key role in cellular functions contributing to the malignant phenotype of tumor cells. We and others have previously demonstrated that RTK ROR1 is overexpressed in ... -
Construction and characterization of a new chimeric antibody against HER2
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-10-09)Aim: Immunotherapy with anti-HER2 antibodies has shown promising results in patients with HER2-positive breast cancer. We have recently reported characterization of a mouse monoclonal antibody (mAb) against HER2, which ... -
Activated monocytes augment TRAIL-mediated cytotoxicity by human NK cells through release of IFN-gamma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-07-25)Natural killer (NK) cells are innate lymphocytes that are able to directly kill tumor cells through different mechanisms including ligation of TNF-related apoptosis-inducing ligand (TRAIL) receptors. Zoledronic acid (ZA) ... -
Doxorubicin sensitizes human tumor cells to NK and T cell-mediated killing by augmented TRAIL-receptor signaling
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-07-25)Doxorubicin (DOX) is an anthracycline antibiotic that is widely used to treat different types of malignancy. In this study, it was studied whether DOX could be used to render tumor cells susceptible to apoptosis by NK and ... -
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-05-22)The proteasome inhibitor bortezomib simultaneously renders tumor cells sensitive to killing by natural killer (NK) cells and resistant to killing by tumor-specific T cells. Here, we show that b-AP15, a novel inhibitor of ... -
Immunophenotypic characterization of the leukemic B-cells from Iranian patients with chronic lymphocytic leukemia : association between CD38 expression and disease progression
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-04-26)Background: Patients with B-cell chronic lymphocytic leukemia (B-CLL) have heterogeneous clinical courses, thus several biological parameters need to be added to the current clinical staging systems to predict disease ... -
RETRACTED: Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-04-24)RETRACTED ARTICLE. Retraction: PLoS One. 2022 May 5;17(5):e0268357. The receptor tyrosine kinase (RTK) ROR1 is overexpressed and of importance for the survival of various malignancies, including lung adenocarcinoma, ... -
Inhibition of proteasome deubiquitinating activity as a novel cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-04-22)Ubiquitin-tagged substrates are degraded by the 26S proteasome, which is a multisubunit complex comprising a proteolytic 20S core particle capped by 19S regulatory particles. The approval of bortezomib for the treatment ... -
Combining [(11)C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-02)BACKGROUND: In vivo imaging using Annexin A5-based radioligands is a powerful technique for visualizing massive cell death, but has been less successful in monitoring the modest cell death typically seen in solid tumors ... -
HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled sel-tagged affibody molecule
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-02)A rapid, reliable method for distinguishing tumors or metastases that overexpress human epidermal growth factor receptor 2 (HER2) from those that do not is highly desired for individualizing therapy and predicting prognoses. ... -
Quitline in smoking cessation : a cost-effectiveness analysis
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2012-08-24)OBJECTIVES: The cost-effectiveness of the Swedish quitline, a nation-wide, free of charge service, is assessed. METHODS: The study was based on data of a sample of 1131 callers enrolled from February 1, 2000 to ... -
Comparison of a high and a low intensity smoking cessation intervention in a dentistry setting in Sweden : a randomized trial
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2012-08-22)BACKGROUND: Tobacco is still the number one life style risk factor for ill health and premature death and also one of the major contributors to oral problems and diseases. Dentistry may be a potential setting for several ... -
Social correlates of cigarette smoking among Icelandic adolescents : a population-based cross-sectional study
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2012-08-22)BACKGROUND: Previous research has shown that between 80 and 90 percent of adult smokers report having started smoking before 18 years of age. Several studies have revealed that multiple social factors influence the likelihood ... -
Symptoms in smokers trying to quit
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2012-08-22)AIMS: To describe the prevalence and intensity of different symptoms in relation to tobacco abstinence. To explore latent dimensions between symptoms in smokers trying to quit. DESIGN: A cross sectional study using ... -
Are non-responders in a quitline evaluation more likely to be smokers?
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2012-08-22)BACKGROUND: In evaluation of smoking cessation programs including surveys and clinical trials the tradition has been to treat non-responders as smokers. The aim of this paper is to assess smoking behaviour of non-responders ...