Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 516
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Unveiling mechanisms of translational control in disease
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-08-29)mRNA translation is a core cellular function that enables rapid alterations in proteome as a response to intra- or extracellular stimuli, with or without the corresponding changes in the transcriptome. Considering its ... -
Lentigo maligna melanoma, a clinicopathological and grenz rays management study
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-22)Lentigo maligna (LM), a neoplastic proliferation of skin melanocytes, is the in situ form of lentigo maligna melanoma (LMM) and it was first described in 1892 by a british surgeon Sir Jonathan Hutchinson. LM and LMM are ... -
Unraveling predictive indicators for therapeutic response in HER2-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-21)Breast cancer is a highly heterogeneous disease, exhibiting significant diversity both in its biological subtypes and clinical manifestations. Biologically directed therapies have revolutionized the treatment landscape for ... -
Using the force : targeting p60AmotL2-mediated invasion in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-28)Mechanotransduction is the process by which cells convert mechanical forces into biochemical signals—and vice versa—thanks to a coordinated cascade of effects regulated by mechanomodulatory and cytoskeletal complexes. These ... -
NK cells in renal cell carcinoma : toward biomarker discovery and improved immunotherapeutic strategies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-27)Renal cell carcinoma (RCC) represents a significant clinical challenge due to its resistance to conventional therapies and its complex tumor microenvironment (TME). RCC's immunogenic nature, characterized by the infiltration ... -
Radiation-induced toxicity and secondary malignant neoplasms in radiotherapy of intrathoracic tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-02-23)Radiation oncology is essential in the treatment of cancer, with approximately fifty percent of oncology patients undergoing radiotherapy (RT) at some stage of their disease management. Significant progress is being made ... -
The cellular thermal shift assay (CETSA) for elucidating drug mechanism of action and resistance in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-02-14)A complete understanding over drug mechanism of action (MoA) is important when attempting to predict treatment outcome or the presence of resistance in patients. Despite decades of scientific efforts, the MoAs of even some ... -
Exploring signaling pathways in endothelial mechanotransduction
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-01-19)Mechanotransduction, the process by which cells sense and convert mechanical forces from their surroundings, plays a pivotal role in cellular function. For vascular endothelial cells, coping with the continuous and significant ... -
How tumour cells hijack apical extrusion and how they can be targeted
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-11-22)Tissue development and cell behavior are influenced not only by chemical signals but also by physical ones. The responses of cells to mechanical forces can range from the immediate adjustment of cell morphology and motility ... -
Sarcoma ecosystems : spatial characterization and prognostic significance
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-11-14)Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies ... -
Art of tumor immunity : extricating hypoxia-driven immunosuppression in the solid tumor microenvironment
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-09-20)The fate of tumors, from initiation to in situ carcinoma and ultimately metastasis, is intricately tied to the balance between the immune system’s effector cytotoxic and tolerogenic immunosuppressive responses, collectively ... -
Targeting MTHFD1 and MTHFD2 as cancer treatment
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-09-18)One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and therefore plays a central role in DNA replication and repair. To sustain rapid proliferation, cancer cells often upregulate their 1C metabolism, ... -
Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-09-15)The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation ... -
Long-term risk for fatal and distant metastatic disease in women with ER-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-08-24)Breast cancer is a major cause of mortality among women worldwide, with estrogen receptor (ER)-positive disease breast cancer being the most common type of breast cancer. A unique feature of ER-positive breast cancer ... -
Precision medicine of ovarian cancer for adults and children : molecular, hereditary and clinical aspects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-08-24)Ovarian cancer was 2018 ranked as the eighth most common cancer diagnosis and cause of death in women. Of these, the most common histological type is high-grade serous carcinoma. There is a diagnostic challenge in the early ... -
Discovering circulating protein biomarkers through in-depth plasma proteomics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-29)Plasma, i.e., the liquid component of blood, is one of the most clinically used samples for biomarker measurement. Despite that plasma proteins and metabolites are the most frequently analysed biomarkers in practice, ... -
Clonal structures and cell interactions in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-29)Despite sharing an identical genome, cells of higher order multicellular organisms display a large degree of phenotypic diversity. This diversity is maintained by a sophisticated regulatory machinery that integrates ... -
The odyssey of MYC transcript from the nucleus to the cytoplasm : the molecular mechanism of the gene gating in human cancer cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-22)Pathological expression of the MYC oncogene is a common denominator in a wide range of cancers and is linked with abnormal cell proliferation. To achieve this status, the MYC gene benefits from being embedded in a region ... -
Diagnostic and prognostic markers in primarily non-smoking related head and neck cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-16)Head and neck cancer (HNC) includes cancers of the oral cavity, the pharynx (i.e., the nasopharynx, the oropharynx, and the hypopharynx), the larynx, the nasal cavity, the paranasal sinuses, and the salivary glands. ... -
Deep learning algorithms for tumor detection in screening mammography
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-04-21)Population-wide mammography screening was fully implemented in Sweden in 1997. The implementation has helped to identify breast cancer at earlier stages and thereby lowered mortality by 30-40%. However, it still has its ...