Doktorsavhandlingar / Doctoral Theses - K6 (KBH): Recent submissions
Now showing items 21-40 of 492
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Moral dilemmas and ethics support in childhood cancer care : a relational perspective
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-11-09)Background: Despite the high survival rate, childhood cancers are still life-threatening diseases that affect everyone involved. The child’s treatment period is intensive and highly specialised, involving various procedures. ... -
Impact of body mass index on outcome, toxicity and pharmacokinetics in patients with acute lymphoblastic leukemia
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-10-27)Background: Overweight and obesity are growing health problems. Obesity has been associated with both a higher risk of contracting cancer and increased cancer-related mortality in adults. The impact in children with cancer, ... -
Immune variation in infectious disease and during development early in life
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-10-25)The human immune system is not only a complex system but a highly dynamic and heterogenous one. It consists of many specialized cells that stimulate and inhibit each other via proteins and physical interactions. And ... -
Genetic vulnerability, environmental exposures and neurodevelopmental disorders : clinical insights and in-vitro consequences
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-08-25)An understanding of how different genetic backgrounds and environmental exposures interact and contribute to diverse medical conditions like neurodevelopmental disorders (NDDs), is key to better health outcomes. A considerable ... -
Transition-aged autistic youth : functioning, quality of life, and internet-delivered psychoeducation
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-08-21)Background: Transition-aged autistic youth, ranging from 16 to 25 years of age, often experience challenges in functioning and have a diminished quality of life (QoL). Several factors have been reported to be associated ... -
Preschool asthma : infant lung function, inflammation and skin barrier function in early life
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-08-18)Background: Asthma is among the most common obstructive respiratory disorders in children, characterized by airway inflammation with features such as wheeze, cough and shortness of breath. Though the etiology behind the ... -
Translational studies on antimetabolic therapies in paediatric oncology
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-08-15)Cure rates for paediatric and adult cancer patients have improved within the last decades. This can partly be explained by implementation of new technologies and methodologies such as the identification of new mutations ... -
Intellectual disability in a forensic psychiatric setting
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-08-15)The main focus of this thesis was to increase knowledge of offenders with ID in forensic psychiatric settings. Offenders with ID constitute a subgroup of offenders, and they have played a peripheral role in previous research ... -
Moral distress and ethical climate in pediatric oncology care
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-08-10)Background: Despite the high survival rates, childhood cancer still is a life-threatening disease. Many ethical dilemmas and constraints challenge healthcare professionals who provide care for these children, causing moral ... -
Frame Running : enabling health improvements through physical exercise in individuals with cerebral palsy
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-05-11)Introduction: Cerebral palsy (CP), caused by a damage to the developing brain, is the most common cause of motor disability in childhood. People with CP may have varying degrees of activity limitation, which affect their ... -
Hemophagocytic lymphohistiocytosis and associations with malignancies
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-05-10)In immune homeostasis, natural killer cells and cytotoxic T cells are responsible for clearance of virus-infected and tumor transformed cells, but also for turning off the immune response. Patients with familial hemophagocytic ... -
Suggested next steps to prevent cervical cancer after surgical treatment for high-grade cervical dysplasia
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-05-09)The risk of cervical cancer among women treated for high-grade cervical dysplasia is more than twofold compared with the general population, and this risk remains elevated for over two decades. In Sweden, cervical cancer ... -
Female autism phenotypes : sex/gender differences in functioning, camouflaging, and eating problems
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-05-02)Background: Autism is a neurodevelopmental condition defined by challenges in social interaction and communication and presence of repetitive patterns in behavior, interests, and activities alongside sensory processing ... -
Manipulation of medicines, necessary in everyday practice for individualised doses in paediatric care
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-04-19)Introduction: Manipulation of medicines is often necessary in the paediatric setting due to lack of medicines suitable for paediatric patients. There are previous short-term frequency studies in different paediatric settings, ... -
Molecular and epidemiological studies of bladder exstrophy and epispadias complex
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-04-13)Bladder exstrophy and epispadias complex is a rare congenital genitourinary malformation involving a midline closure defect, leaving an open bladder on the lower abdominal wall. In Sweden, the prevalence is 3:100 ... -
Lifelong health and well-being in men born with hypospadias
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-04-05)Hypospadias is a congenital malformation defined by an ectopic placement of the urethral orifice along the ventral side of the penis, with a large variation in phenotype from distal to proximal. There are both genetic and ... -
Prevention of growth failure caused by glucocorticoid treatment
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-03-10)Children with chronic inflammation often suffer from growth failure and many of these children are treated with high doses of glucocorticoids (GCs). However, the underlying mechanisms of growth failure under conditions of ... -
Brain structure and function in primary adrenal insufficiency
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-02-24)Individuals with primary adrenal insufficiency (PAI), i.e., congenital adrenal hyperplasia (CAH) and autoimmune Addison’s disease (AAD), suffer from impaired production of the adrenal gland hormones cortisol and aldosterone, ... -
Identifying and targeting vulnerabilities in cancers that metastasize to the bone and bone marrow
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-02-16)Evolving technologies enable scientist to ask and seek answers to advanced questions, above and beyond. During the past decade single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of biology, in ... -
Maternal stress and allergic disease in offspring
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-01-03)The theory of developmental origins of health and disease (DOHaD), hypothesize that diseases like allergy is formed in-utero and early life by interaction between adverse environmental factors and genetic predisposition. ...