Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology
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Strategies for expanding organ availability and improving transplant outcomes
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-08-20)Organ transplantation is a lifesaving treatment for patients suffering from end stage liver disease or heart failure. For patients with chronic kidney disease, transplantation reduces morbidity and decreases mortality. ... -
Perspectives on metal-on-metal hip resurfacing
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-07-05)The overall aim of this thesis was to study patients with metal-on-metal hip resurfacing (MoM-HR). More specifically, we investigated if there are any advantages in patient-reported outcome measures (PROM) after MoM-HR ... -
Tumour-draining lymph nodes in head and neck cancer : immunological signatures and clinical implications
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-23)The lymphatic system is responsible for orchestrating immune responses, particularly in cancer. Oral squamous cell carcinoma (OSCC) represents a significant clinical challenge, with lymphatic metastasis being a crucial ... -
Delineating cell types and toxicity in human ovaries from birth to sexual maturity
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-06)The ovary contains the female germ cells known as oocytes, which are essential for female fertility. The immature oocytes reside within primordial follicles in the ovarian cortex and are referred to as the ovarian reserve. ... -
Innovations in pancreatology
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-04-26)In paper I, we explored the presence and potential significance of intracystic pancreatic microbiomes in patients with suspected pancreatic cystic neoplasms (PCNs), who underwent pancreatic surgery. Paired samples of plasma ... -
Developing an embryonic stem cell-based cell product for age-related macular degeneration
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-04-22)Age-related macular degeneration (AMD) remains a major cause of blindness with no current cure. With the increasing ageing population in the developed world, a high number of AMD patients is expected. AMD can be distinguished ... -
Pathogenesis of IgA nephropathy and diabetic kidney disease : linking molecular profile to morphological and clinical picture
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-02-26)Background: More than 10% of the global population suffers from chronic kidney disease (CKD), which poses a large impact on society and, more importantly, the life of the affected patient. Two of the most common causes of ... -
Targeting the ovary : mapping mechanisms to link endocrine-disrupting chemicals to female fertility
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-02-09)In recent decades, growing attention has been paid to endocrine-disrupting chemicals (EDCs) as mounting evidence suggests that they can cause detrimental reproductive outcomes in animals and humans. Even though epidemiological ... -
Airway hyperresponsiveness and viral recognizing toll-like receptors
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-01-18)Common colds caused by viruses are, in healthy individuals, usually self-limited and with relatively mild symptoms. In asthmatic individuals, respiratory viruses can burst the defense immune system and trigger asthma ... -
Treatment of cholelithiasis and acute cholecystitis : surgical safety in gallstone surgery
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-11-06)INTRODUCTION: Laparoscopic cholecystectomy is one of the most frequently performed surgical procedures worldwide, with nearly 14,000 operations per year in Sweden alone. Recurrent biliary colic or acute cholecystitis are ... -
Mesenchymal stem cell regeneration and differentiation after anti inflammatory drug exposure
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-11-06)Traumatic and degenerative pathologies of the musculoskeletal system are common and often involve injuries of multiple mesenchymal tissues including bone, cartilage, tendons and ligaments. Medical intervention is frequently ... -
Contrast-enhanced ultrasound in children
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-10-27)Background: Contrast-enhanced ultrasound (CEUS) is a diagnostic tool that is used for many applications in adults. Many of these applications are considered “off-label” use but still play an important role in diagnostic ... -
Growing up with one ear : central auditory structure and function in unilateral ear canal atresia
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-10-17)The following thesis aims to give more insight into the functional and structural response of the central auditory system to congenital unilateral ear canal atresia (UCA) and the accompanying asymmetric hearing with ... -
Multimodal treatment of gastric cancer : assessment of tumor regression and the role of minimally invasive surgery
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-08-23)The generally poor prognosis of advanced gastric cancer (AGC) has led to the development of multimodal therapeutic protocols in which surgery is combined with systemic treatment, perioperative chemotherapy being the preferred ... -
Immune cell composition and cytokine expression in the pregnant and non-pregnant uterus
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-05-23)The success of implantation and further development of the embryo is heavily dependent on the endometrial immune cell composition and its ability to communicate with fetal semi-allogeneic trophoblast cells. Although our ... -
Microcirculation in chronic kidney disease : from injury targets to potential therapeutics
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-05-08)Chronic kidney disease (CKD) is a major public health problem worldwide, and patients with end-stage kidney disease (ESKD) are at increased risk of developing cardiovascular complications. Small artery dysfunction is a ... -
Chronic kidney disease and early vascular ageing : pinpointing culprits of injury and targets for intervention
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-04-19)Chronic kidney disease (CKD) is a progressive non-communicable disease, and a clinical model of premature ageing. Approximately 1 in 10 people globally have CKD, defined as abnormalities of kidney structure and/or function ... -
Children with congenital unilateral sensorineural hearing loss : etiology, newborn diagnostics, and hearing aid amplification
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-03-08)Congenital unilateral sensorineural hearing loss (uSNHL) comprises about 25% of the sensorineural hearing losses (SNHLs) found through newborn hearing screening (NHS) programs. Even if children with congenital uSNHL struggle ... -
Mangement of acute cholecystitis : surgery, drainage and gallbladder aspiration
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-01-27)Background: Early laparoscopic cholecystectomy is considered the standard of care for patients admitted with acute cholecystitis. Nevertheless, a large proportion of patients admitted for acute cholecystitis are managed ... -
Idiopathic scoliosis : aspects on surgical and non-surgical treatment
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2023-01-23)The term scoliosis has been used to describe conditions that lead to deformation of the spine. It derives from the ancient Greek ‘σκολίωσις’ and the root word ‘σκολιός’ which means ‘bent or crooked’. In its most common ...