Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition: Recent submissions
Now showing items 1-20 of 316
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Deciphering mechanisms that regulate aging in Caenorhabditis elegans
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-05-15)Aging is a multifaceted and poorly understood process characterized by physiological changes that culminate in the decline of an organism's functions. The research field of Biology of Aging aims to provide insight into ... -
Primary cilia in human neuron differentiation
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-04-23)Primary (non-motile) cilia have long been overlooked, considered vestigial organelles lacking specific functions. In humans, all cell types except sperm, ependymal and bronchial epithelial cells, and oviduct cells extend ... -
Antioxidants stimulate BACH1-dependent tumor angiogenesis
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2023-11-06)Reactive oxygen species (ROS) can inactivate tumor suppressors, activate transcription factors, and stimulate tumor progression, which partly explains the belief that antioxidant supplements should fight cancer. Yet, despite ... -
An RNA story, from chromatin to protein
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2023-09-21)RNA functions expand well over just coding for protein effectors. Non-coding RNAs oversee translation, RNA processing, and spatial organization of the cellular space, therefore participating in the regulation of almost any ... -
Role and mechanism of estrogen receptor beta in the physiology of the ovary and colon
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2023-08-31)Estrogen regulates a variety of important physiological functions in both males and females, where the regulation of female reproduction and the development of sexual organs are typical examples. The effects of estrogen ... -
Cell-matrix interactions : master regulators of cancer cell fate?
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2023-05-17)The development and homeostasis of a multicellular organism require fundamental biological processes like cell proliferation, cell differentiation, cell migration, and controlled cell death. The extracellular matrix (ECM) ... -
Microtubule and spindle pole body regulation in the budding yeast mitotic spindle
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2023-03-07)The microtubule organizing center (MTOC) is a specialized structure with a main function in microtubule (MT) nucleation and organization. In higher eukaryotes, the main MTOC is known as the centrosome, and its functional ... -
Microtubule and chromosome dynamics during mitosis in budding yeast
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2023-02-02)As a cell divides, DNA must be replicated and faithfully segregated between the mother and daughter cells. This segregation is facilitated by the mitotic spindle, assembled to pull sister chromatids apart as the cell ... -
Biomimetic spider silk and bioactive hydrogels formed by engineered recombinant spider silk proteins
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-11-18)Spider silk is a unique material and its properties have fascinated material scientists, biologists and physicians for decades. Spider silk display one of the highest toughness found among fibers in nature, is used by ... -
From gene therapy to somatic mutagenesis : insights into the common Hutchinson-Gilford progeria syndrome mutation
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-10-20)Mutations of the human genome can cause a large variety of genetic diseases, such as the Hutchinson-Gilford progeria syndrome (HGPS). The LMNA c.1824C>T point mutation amplifies a cryptic splice event within exon 11 of the ... -
Elucidating the principles of gene regulation in the human genome
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-07-28)Gene regulation is largely controlled by two groups of cis-regulatory elements: (i) promoters that initiate stable mRNAs and (ii) enhancers that generate bidirectionally transcribed unstable enhancer RNAs (eRNAs). While ... -
HealthyMoms : a smartphone application to promote healthy weight gain, diet and physical activity during pregnancy : a randomized controlled trial
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-06-01)Background: The prevalence of overweight and obesity is a major public health concern, also among pregnant women. Alarmingly, around half of pregnant women in high income countries exceed the recommendations for an optimal ... -
Estrogen regulation of non-Hodgkin lymphomas and its underlying mechanisms
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-05-30)Most non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL), show a higher male to female incidence ratio. The reason for this is not clear, but epidemiological and ... -
Small Cajal body-associated RNA 2 and RNA-binding protein WRAP53β in DNA repair and Hoyeraal-Hreidarsson syndrome
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-05-23)The DNA in our cells can be damaged through many different mechanisms and correct repair of DNA lesions is of utmost importance to ensure genomic integrity and prevent alteration in the genetic code contributing to diseases ... -
Genetic analysis of cell cycle and chromatin regulation in quiescent fission yeast cells
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-05-16)During proliferation, cells produce their genetic materials to increase the number of cells, while in the absence of nutrients or by the induction of stimulus, the proliferative phase is stopped and entry into quiescence ... -
Hunter-gatherer-annotator science : characterizing regulatory elements in the genome of dog and zebrafish with public and not yet public data
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-05-12)In order to study gene regulation, large amounts of sequencing data are necessary. We can either generate (hunt) them ourselves or use (gather) publicly available data sets. In order to guarantee the reliability and ... -
Evaluation, synthesis and imaging of therapeutic oligonucleotides
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-04-06)A new method for the ³⁴S isotope labelling of phosphorothioate oligonucleotides is reported which allows a practical synthesis of site specifically labeled oligonucleotides. Several applications of this method are reported. ... -
Mechanisms behind Smc5/6 transcriptional regulation and cohesin-mediated chromosome organisation
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-03-30)The eukaryotic family of Structural Maintenance of Chromosomes (SMC) complexes are multi-subunit, ring-like protein complexes and include condensin, cohesin and the Smc5/6 complex (Smc5/6). Considered as an entity, this ... -
Peptide nucleic acid conjugates as artificial ribonucleases : Cu2+ and Zn2+-dependent PNAzymes
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-02-24)Synthetic modified oligonucleotides are gaining momentum as powerful therapeutic tools used in the treatment of life-threatening diseases. Degradation of disease-related RNA sequences is one of the goals achieved with ... -
Development and synthesis of oligonucleotide building blocks and conjugates for therapeutic applications
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-02-04)The research and development of oligonucleotide therapeutics has been a topic of great importance in life sciences. The potential to treat rare genetic diseases can be demonstrated simply by highlighting the increasing ...