Doktorsavhandlingar / Doctoral Theses - D1 (KI DS): Recent submissions
Now showing items 81-100 of 177
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Clinical and surgical aspects of treatment of degenerative and traumatic rotator cuff tears
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-05-23)Pain caused by rotator cuff pathology or tear is a major source of discomfort and dysfunction in the shoulder joint. The prevalence of rotator cuff tear increases with age and also as the workforce becomes older. The number ... -
Implantable defibrillator at end of life with emphasis on deactivation and guideline compliance
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-04-26)Introduction: Implantable Cardioverter Defibrillators (ICD) have been demonstrated to improve survival in cardiac patients with high risk for sudden death. The incidence of ICD implantations is increasing worldwide. The ... -
Aspects of diverting stoma and ERAS in rectal cancer surgery
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-04-25)Annually, nearly 2000 patients are diagnosed with rectal cancer in Sweden. To date, the only known curative treatment is surgery and low anterior resection (LAR) is the operation of choice for tumours in the middle rectum. ... -
Coping and emotional well-being in patients with chronic heart failure
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2015-08-19)Background: Chronic heart failure (CHF) is a serious illness, with a profound impact on the patient. Poor health-related quality of life (HRQoL) as well as anxiety and depression are prevalent in CHF and predict mortality ... -
Afflicted by an acute myocardial infarction : patients' thoughts, feelings and actions prior to care-seeking
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2015-03-20)Introduction: Acute myocardial infarction (AMI) is the most prevalent cause of death in Europe. The primary aim of early medical contact when afflicted by an AMI is to be able to treat fatal arrhythmias and to save heart ... -
Inflammatory bowel disease and complementary and alternative medicine : the perspectives of patients and healthcare professionals
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2015-03-17)Background: Inflammatory bowel disease (IBD) is a term that covers ulcerative colitis (UC) and Crohn’s disease (CD). The causes of IBD are unknown and the incidence is increasing. IBD is a lifelong disease with severe ... -
Predicting prostate cancer : on the use of biomarkers in prostate cancer diagnostics
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2015-01-08)Aims: The aims of this thesis work were to answer the following questions. Paper I: How prevalent is testing and retesting with prostate-specific antigen (PSA)?; Paper II: Is a genetic score based on single-nucleotide ... -
Prostate cancer diagnostics : complications and ways to reduce unnecessary biopsies
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2014-12-29)Introduction: Prostate cancer is the most common form of cancer among men in Sweden. There has been a rapid increase in the incidence rate of prostate cancer following the introduction of PSA testing and, today, more ... -
Post-polio syndrome : analysis of inflammation and immune modulation
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2014-12-19)Poliomyelitis is a viral infection, which affects the anterior horn cells of the spinal cord leaving patients with different levels and distribution of muscle weakness and loss of, or decreased, function. This situation ... -
The pelvic floor and genital prolapse : a clinical, physiological and radiological study
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2000-05-05)Objective: To determine the frequency of concomitant colorectal disorders in patients with rectocele, and to assess any such association with rectocele; to investigate if paradoxical sphincter reaction (PSR) is influenced ... -
Displaced femoral neck fractures : studies on osteosynthesis and total hip arthroplasty
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2000-04-28)The treatment of femoral neck fractures has for many years in Sweden been reduction and osteosynthesis with nails or screws. For displaced fractures the risk of complications such as avascular necrosis and non-union is up ... -
Combined sulphonylurea and insulin treatment for type 2 diabetes mellitus : metabolic and electrophysiological studies
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2000-03-10)Type 2 diabetes is a prevalent disorder characterized by elevated blood glucose levels and associated with increased morbidity from micro- and macrovascular complications. Lowering of blood glucose has been shown to reduce ... -
Prognostic implications of exercise induced and ambulatory ischemia in patients with stable angina pectoris
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 1999-11-17)Results from exercise testing and ambulatory ECG registration were studied in 809 patients with stable angina pectoris; special attention was paid to signs of ischemia during both tests. Autonomic nervous system activity ... -
In vitro studies on intestinal epithelial cell proliferation : effects of cytokines, Helicobacter pylori, serotonin and neuroendocrine peptides
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 1999-10-29)Previous studies suggest that bacteria and bacterial metabolites, proinflammatory cytokines, neuroendocrine peptides and amines may participate in the regulation of the gastrointestinal-epithelial cell kinetics. The ... -
Studies on glucagon secretion in patients with type 1 diabetes : clinical and experimental studies
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 1999-10-22)Hypoglycaernia is the main limiting factor reaching normo-glycaemia in type I diabetic patients. The risk of hypoglycaemia increases usually with improvements in metabolic control. The annual prevalence of severe episodes ... -
Sphincter injuries and anal incontinence after vaginal delivery : a clinical and physiological study
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 1999-08-27)Objective: To investigate the frequency and degree of anal incontinence after vaginal delivery in primiparous women, to determine risk factors for obstetric sphincter tears and to evaluate outcome of primary repair, to ... -
Acute lung injury : incidence and predictors of outcome with special reference to inhaled nitric oxide
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 1999-04-16)This work started out as a critical examination of the initial clinical experiences with inhalation of nitric oxide (INO) to patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in Scandinavia ... -
Rectal prolapse, internal rectal intussusception and the ripstein rectopexy : a clinical, physiological and radiological study
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 1998-11-13)The aim of these studies was to increase the knowledge about rectal prolapse and internal rectal intussusception, with special reference to bowel function and treatment with the Ripstein rectopexy. Results after the ... -
Ghrelin action on gastrointestinal functions and appetite in rat and man
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2006-04-21)To study the effect of ghrelin on the contractility of smooth muscle strips in vitro as well as the effects on fasting small bowel motility and acid secretion in vivo in rats and gastric emptying in rats and humans. To ... -
Evaluation and treatment of pelvic organ prolapse : clinical, radiological and histopathological aspects
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2004-12-31)Objective: To assess the use of cystodefecoperitoneography (CDP) in clinical and radiological diagnosis of cystocele; to study the correlation between clinical and radiological findings at CDP and to evaluate if anatomical ...