Doktorsavhandlingar / Doctoral Theses - C2 (MBB): Recent submissions
Now showing items 1-20 of 308
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Functional characterization of protective antibodies in murine models of rheumatoid arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-20)Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease, characterized by chronic, erosive polyarthritis and by the presence of various autoantibodies in serum and synovial fluid. There are many different ... -
Pathogenic mitochondrial DNA point mutations in the immune system : ‘A tale of two cities’
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-20)Study I: The Effects of High Heteroplasmic Pathogenic mt-tRNA Mutations on Immunity. High levels of heteroplasmic pathogenic mtDNA mutations in mitochondrial tRNA (mt-tRNA) genes can severely disrupt mitochondrial translation ... -
Genome and prognosis models : towards the personalized therapy for patients with B-cell lymphoma
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-19)B-cell lymphoma is a heterogeneous cancer derived from B lymphocytes, with over 60 subtypes classified by the World Health Organization (WHO). Common subtypes include diffuse large B-cell lymphoma (DLBCL), follicular ... -
Dynamics of transcriptomic and epigenomic states in mouse and human central nervous system cells in multiple sclerosis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-12)Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by immunologically mediated demyelination in the central nervous system (CNS). Oligodendrocytes, a type of glial cell in the CNS, are responsible for ... -
Deciphering oligodendrocyte lineage heterogeneity in development and disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-07-30)Oligodendrocytes are the myelinating glia of the central nervous system (CNS). By forming lipid-rich myelin membranes that spirally enwrap axonal segments, oligodendrocytes ensure rapid saltatory impulse propagation, ... -
A biophysical symphony : the interplay of factors determining microRNA-34a activity
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-05-28)microRNAs (miRNAs) play a pivotal role as post-transcriptional regulators in gene expression, adding a layer of complexity to the intricate system of molecular interactions within cells. Despite their short length, miRNAs ... -
Decoding the symphony : illuminating the mammalian mitochondrial RNA binding proteome with a novel interactome approach
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-05-14)Mitochondria, colloquially known as the "powerhouses of the cell" are crucial for generating cellular energy through a process known as oxidative phosphorylation (OXPHOS). These minute but mighty organelles are distinct ... -
DNA tools for imaging and manipulation of biological samples
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-26)Spatial organization within biological systems is important for understanding mechanisms underlying health and disease. This thesis investigates the role of spatial distribution at cellular and molecular levels, utilizing ... -
Navigating the oligodendroglial chromatin landscape using high-throughput single-cell epigenomics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-19)The central nervous system (CNS), which includes the brain and spinal cord, is a remarkably complex system composed of billions of cells controlling everything ranging from basic metabolic functions to higher executive ... -
Lineage, cell state and cell identity in the developing human brain
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-04)Organisms are complex systems consisting of thousands of distinct types of cells that perform a wide array of functions, yet for the most part share the same DNA. To regulate the expression of genes, the genome contains a ... -
Development and function of GABAergic neurons in health and in a predisposition model of schizophrenia
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-03-21)In this thesis, I present four studies which examine i) the role of transcript factor Sox6 in the development and maintenance of cortical Sst interneurons, ii) the involvement of cortical neurogliaform cells (NGFCs) in the ... -
Imaging the spatial organization of healthy human brain and glioblastoma
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)Multicellular biological systems have a single genetic plan that contains the set of instructions to shape the three-dimensional architecture of specialized tissues and organs. The genetic plan is contained in the DNA, and ... -
Regulation of mtDNA gene expression and the role of respiratory chain supercomplexes in mammalian mitochondria
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)Mitochondria are cellular organelles found in nearly all eukaryotic cells, where they fulfill a plethora of functions, including energy conversion. They harness energy from carbon sources to synthesize adenosine triphosphate ... -
The role of endoglin in vascular patterning and malformation across diverse vascular beds
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-01-09)During development, numerous processes must be finely orchestrated to construct a functional vasculature, essential to sustain life. Hereditary haemorrhagic telangiectasia is a disease characterised by the development of ... -
Impact of commonly prescribed drugs on the risk of colorectal cancer
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-11-23)Colorectal cancer (CRC) stands as the fourth most prevalent cancer worldwide and the third most common in Sweden. Characterized by a protracted progression stage and insidious onset, CRC poses a considerable challenge for ... -
Beyond conventional care : developing novel therapeutic approaches to combat arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-10-30)Rheumatoid arthritis (RA) is an autoimmune disorder without a definitive cure. Although RA is driven by systemic autoimmunity, its most pronounced manifestation is organspecific inflammation, particularly synovitis in ... -
Novel methods of tandem mass spectrometry in life sciences
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-09-06)Mass spectrometry (MS) is a powerful analytical technique widely employed for isotopic analysis and species identification in numerous research fields. Isotopic analysis involves precisely measuring stable isotopes within ... -
Computational and chemical approaches to drug repurposing
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-08-31)Drug repurposing, which entails discovering novel therapeutic applications for already existing drugs, provides numerous benefits compared to conventional drug discovery methods. This strategy can be pursued through two ... -
Functional screening and molecular characterisation of small proteins
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-08-23)Proteins are one of the main drivers of cellular function. Most known proteins constitute various hundred amino acids, but growing evidence suggests that additionally thousands of short open reading frames (sORFs) are ... -
Targeting glutathione peroxidases : identifying environmental modulators, and screening for novel small molecule inhibitors
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-05-22)Glutathione peroxidases (GPXs) are a family of selenoproteins that are critical regulators of reactive oxygen species (ROS) in the cell, specifically hydroperoxides like hydrogen peroxide (H2O2). ROS are important for ...